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Prevention Measures for COVID-19 and Changes in Kawasaki Disease Incidence.
Katsumata, Nobuyuki; Harama, Daisuke; Toda, Takako; Sunaga, Yuto; Yoshizawa, Masashi; Kono, Yosuke; Hasebe, Yohei; Koizumi, Keiichi; Hoshiai, Minako; Saito, Tomohiro; Hokibara, Sho; Kobayashi, Koji; Goto, Miwa; Sano, Tomoaki; Tsuruta, Makoto; Nakamura, Makoto; Mizorogi, Sonoko; Ohta, Masanori; Mochizuki, Mie; Sato, Hiroki; Yokomichi, Hiroshi; Inukai, Takeshi.
  • Katsumata N; Department of Pediatrics, University of Yamanashi.
  • Harama D; Departments of Neonatology, Yamanashi Central Prefectural Hospital.
  • Toda T; Department of Pediatrics, University of Yamanashi.
  • Sunaga Y; Department of Pediatrics, Yamanashi Central Prefectural Hospital.
  • Yoshizawa M; Department of Pediatrics, University of Yamanashi.
  • Kono Y; Department of Pediatrics, University of Yamanashi.
  • Hasebe Y; Department of Pediatrics, University of Yamanashi.
  • Koizumi K; Department of Pediatrics, University of Yamanashi.
  • Hoshiai M; Department of Pediatrics, University of Yamanashi.
  • Saito T; Department of Pediatrics, Fujiyoshida Municipal Hospital.
  • Hokibara S; Department of Pediatrics, Yamanashi Central Prefectural Hospital.
  • Kobayashi K; Department of Pediatrics, Yamanashi Central Prefectural Hospital.
  • Goto M; Department of Pediatrics, Kofu Municipal Hospital.
  • Sano T; Department of Pediatrics, Yamanashi Kosei Hospital.
  • Tsuruta M; Department of Pediatrics, National Hospital Organization Kofu National Hospital.
  • Nakamura M; Department of Pediatrics, Yamanashi Red Cross Hospital.
  • Mizorogi S; Department of Pediatrics, Kofu-kyoritsu Hospital.
  • Ohta M; Department of Pediatrics, Fujiyoshida Municipal Hospital.
  • Mochizuki M; Department of Pediatrics, Nirasaki City Hospital.
  • Sato H; Department of Pediatrics, Tsuru Municipal General Hospital.
  • Yokomichi H; Department of Pediatrics, Kyonan Medical Center Fujikawa Hospital.
  • Inukai T; Department of Pediatrics, Suwa Central Hospital.
J Epidemiol ; 31(11): 573-580, 2021 11 05.
Article in English | MEDLINE | ID: covidwho-1477690
ABSTRACT

BACKGROUND:

Kawasaki disease is suspected to be triggered by previous infection. The prevention measures for coronavirus disease 2019 (COVID-19) have reportedly reduced transmission of certain infectious diseases. Under these circumstances, the prevention measures for COVID-19 may reduce the incidence of Kawasaki disease.

METHODS:

We conducted a retrospective study using registration datasets of patients with Kawasaki disease who were diagnosed in all 11 inpatient pediatric facilities in Yamanashi Prefecture. The eligible cases were 595 cases that were diagnosed before the COVID-19 pandemic (from January 2015 through February 2020) and 38 cases that were diagnosed during the COVID-19 pandemic (from March through November 2020). Incidence of several infectious disease were evaluated using data from the Infectious Disease Weekly Report conducted by the National Institute of Infectious Diseases.

RESULTS:

Epidemics of various infectious diseases generally remained at low levels during the first 9 months (March through November 2020) of the COVID-19 pandemic. Moreover, the incidence of COVID-19 was 50-80 times lower than the incidence in European countries and the United States. The total number of 38 cases with Kawasaki disease for the 9 months during the COVID-19 pandemic was 46.3% (-3.5 standard deviations [SDs] of the average [82.0; SD, 12.7 cases] for the corresponding 9 months of the previous 5 years. None of the 38 cases was determined to be triggered by COVID-19 based on their medical histories and negative results of severe acute respiratory syndrome coronavirus 2 testing at admission.

CONCLUSION:

These observations provide a new epidemiological evidence for the notion that Kawasaki disease is triggered by major infectious diseases in children.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics / COVID-19 / Mucocutaneous Lymph Node Syndrome Type of study: Diagnostic study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn Country/Region as subject: Asia Language: English Journal: J Epidemiol Journal subject: Epidemiology Year: 2021 Document Type: Article

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics / COVID-19 / Mucocutaneous Lymph Node Syndrome Type of study: Diagnostic study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn Country/Region as subject: Asia Language: English Journal: J Epidemiol Journal subject: Epidemiology Year: 2021 Document Type: Article