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Magnetically Enhanced Liquid SERS for Ultrasensitive Analysis of Bacterial and SARS-CoV-2 Biomarkers.
Ji, Zhang; Zhang, Chuan; Ye, Yang; Ji, Jiali; Dong, Hongguang; Forsberg, Erik; Cheng, Xiaoyu; He, Sailing.
  • Ji Z; National Engineering Research Center for Optical Instruments, College of Optical Science and Engineering, Zhejiang University, Hangzhou, China.
  • Zhang C; National Engineering Research Center for Optical Instruments, College of Optical Science and Engineering, Zhejiang University, Hangzhou, China.
  • Ye Y; National Engineering Research Center for Optical Instruments, College of Optical Science and Engineering, Zhejiang University, Hangzhou, China.
  • Ji J; Ningbo Research Institute, Ningbo, China.
  • Dong H; ZJU-TU/e Joint Research Institute of Design, Optoelectronic and Sensing, Hangzhou, China.
  • Forsberg E; National Engineering Research Center for Optical Instruments, College of Optical Science and Engineering, Zhejiang University, Hangzhou, China.
  • Cheng X; National Engineering Research Center for Optical Instruments, College of Optical Science and Engineering, Zhejiang University, Hangzhou, China.
  • He S; National Engineering Research Center for Optical Instruments, College of Optical Science and Engineering, Zhejiang University, Hangzhou, China.
Front Bioeng Biotechnol ; 9: 735711, 2021.
Article in English | MEDLINE | ID: covidwho-1477801
ABSTRACT
In this work, it is shown that surface-enhanced Raman scattering (SERS) measurements can be performed using liquid platforms to perform bioanalysis at sub-pM concentrations. Using magnetic enrichment with gold-coated magnetic nanoparticles, the high sensitivity was verified with nucleic acid and protein targets. The former was performed with a DNA fragment associated with the bacteria Staphylococcus aureus, and the latter using IgG antibody, a biomarker for COVID-19 screening. It is anticipated that this work will inspire studies on ultrasensitive SERS analyzers suitable for large-scale applications, which is particularly important for in vitro diagnostics and environmental studies.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Front Bioeng Biotechnol Year: 2021 Document Type: Article Affiliation country: Fbioe.2021.735711

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Front Bioeng Biotechnol Year: 2021 Document Type: Article Affiliation country: Fbioe.2021.735711