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Commonalities Between ARDS, Pulmonary Fibrosis and COVID-19: The Potential of Autotaxin as a Therapeutic Target.
Ntatsoulis, Konstantinos; Karampitsakos, Theodoros; Tsitoura, Eliza; Stylianaki, Elli-Anna; Matralis, Alexios N; Tzouvelekis, Argyrios; Antoniou, Katerina; Aidinis, Vassilis.
  • Ntatsoulis K; Institute of Bio-Innovation, Biomedical Sciences Research Center Alexander Fleming, Athens, Greece.
  • Karampitsakos T; Department of Respiratory Medicine, School of Medicine, University of Patras, Patras, Greece.
  • Tsitoura E; Laboratory of Molecular & Cellular Pneumonology, Department of Respiratory Medicine, School of Medicine, University of Crete, Heraklion, Greece.
  • Stylianaki EA; Institute of Bio-Innovation, Biomedical Sciences Research Center Alexander Fleming, Athens, Greece.
  • Matralis AN; Institute of Bio-Innovation, Biomedical Sciences Research Center Alexander Fleming, Athens, Greece.
  • Tzouvelekis A; Department of Respiratory Medicine, School of Medicine, University of Patras, Patras, Greece.
  • Antoniou K; Laboratory of Molecular & Cellular Pneumonology, Department of Respiratory Medicine, School of Medicine, University of Crete, Heraklion, Greece.
  • Aidinis V; Institute of Bio-Innovation, Biomedical Sciences Research Center Alexander Fleming, Athens, Greece.
Front Immunol ; 12: 687397, 2021.
Article in English | MEDLINE | ID: covidwho-1477818
ABSTRACT
Severe COVID-19 is characterized by acute respiratory distress syndrome (ARDS)-like hyperinflammation and endothelial dysfunction, that can lead to respiratory and multi organ failure and death. Interstitial lung diseases (ILD) and pulmonary fibrosis confer an increased risk for severe disease, while a subset of COVID-19-related ARDS surviving patients will develop a fibroproliferative response that can persist post hospitalization. Autotaxin (ATX) is a secreted lysophospholipase D, largely responsible for the extracellular production of lysophosphatidic acid (LPA), a pleiotropic signaling lysophospholipid with multiple effects in pulmonary and immune cells. In this review, we discuss the similarities of COVID-19, ARDS and ILDs, and suggest ATX as a possible pathologic link and a potential common therapeutic target.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Fibrosis / Respiratory Distress Syndrome / Phosphoric Diester Hydrolases / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.687397

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Fibrosis / Respiratory Distress Syndrome / Phosphoric Diester Hydrolases / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.687397