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Alveolar Regeneration in COVID-19 Patients: A Network Perspective.
Gupta, Shishir K; Srivastava, Mugdha; Minocha, Rashmi; Akash, Aman; Dangwal, Seema; Dandekar, Thomas.
  • Gupta SK; Functional Genomics & Systems Biology Group, Department of Bioinformatics, Biocenter, Am Hubland, University of Wuerzburg, D-97074 Wuerzburg, Germany.
  • Srivastava M; Functional Genomics & Systems Biology Group, Department of Bioinformatics, Biocenter, Am Hubland, University of Wuerzburg, D-97074 Wuerzburg, Germany.
  • Minocha R; Core Unit Systems Medicine, University of Wuerzburg, D-97080 Wuerzburg, Germany.
  • Akash A; Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
  • Dangwal S; Functional Genomics & Systems Biology Group, Department of Bioinformatics, Biocenter, Am Hubland, University of Wuerzburg, D-97074 Wuerzburg, Germany.
  • Dandekar T; Stanford Cardiovascular Institute, Department of Medicine Stanford University School of Medicine, Palo Alto, CA 94305-5101, USA.
Int J Mol Sci ; 22(20)2021 Oct 19.
Article in English | MEDLINE | ID: covidwho-1477960
ABSTRACT
A viral infection involves entry and replication of viral nucleic acid in a host organism, subsequently leading to biochemical and structural alterations in the host cell. In the case of SARS-CoV-2 viral infection, over-activation of the host immune system may lead to lung damage. Albeit the regeneration and fibrotic repair processes being the two protective host responses, prolonged injury may lead to excessive fibrosis, a pathological state that can result in lung collapse. In this review, we discuss regeneration and fibrosis processes in response to SARS-CoV-2 and provide our viewpoint on the triggering of alveolar regeneration in coronavirus disease 2019 (COVID-19) patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Regeneration / COVID-19 / Lung Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms222011279

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Regeneration / COVID-19 / Lung Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms222011279