Modification of immunosuppressive agents in a kidney transplant recipient with COVID-19 and acute kidney injury.
J Infect Dev Ctries
; 15(9): 1273-1276, 2021 09 30.
Article
in English
| MEDLINE | ID: covidwho-1478140
ABSTRACT
INTRODUCTION:
An outbreak of coronavirus disease-19 (COVID-19) has occurred in different parts of the world. Although a large piece of information regarding the epidemiology, clinical features, and management of COVID-19 has been reported in the general population, there is very limited data regarding organ transplant recipients, particularly regarding the management of maintenance immunosuppressive agents during infection.METHODOLOGY:
We described a case of kidney transplant recipient from Thailand who had COVID-19 pneumonia and severe acute kidney injury.RESULTS:
The patient's serum creatinine peaked at 7.0 mg/dL on day 15 of illness and returned to baseline value of 2.0 mg/dL on day 26 of illness. We have shown how we modified tacrolimus, mycophenolate, and steroids in the patient who had received favipiravir and lopinavir/ritonavir for COVID-19 pneumonia.CONCLUSIONS:
In this case, successful modification of this immunosuppressive regimen was accomplished to reduce drug interaction complications, aiming to avoid calcineurin inhibitor nephrotoxicity while maintaining appropriate levels of immunosuppression to prevent organ rejection and to promote the patient's recovery from infection.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Acute Kidney Injury
/
COVID-19 Drug Treatment
/
Immunosuppressive Agents
Type of study:
Case report
/
Prognostic study
Limits:
Adult
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
J Infect Dev Ctries
Journal subject:
Communicable Diseases
Year:
2021
Document Type:
Article
Affiliation country:
Jidc.13176
Similar
MEDLINE
...
LILACS
LIS