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Vitamin D-related polymorphisms and vitamin D levels as risk biomarkers of COVID-19 disease severity.
Freitas, Ana Teresa; Calhau, Conceição; Antunes, Gonçalo; Araújo, Beatriz; Bandeira, Matilde; Barreira, Sofia; Bazenga, Filipa; Braz, Sandra; Caldeira, Daniel; Santos, Susana Constantino Rosa; Faria, Ana; Faria, Daniel; Fraga, Marta; Nogueira-Garcia, Beatriz; Gonçalves, Lúcia; Kovalchuk, Pavlo; Lacerda, Luísa; Lopes, Hugo; Luís, Daniel; Medeiros, Fábio; Melo, Ana M P; Melo-Cristino, José; Miranda, Ana; Pereira, Clara; Pinto, Ana Teresa; Pinto, João; Proença, Helena; Ramos, Angélica; Rato, João P R; Rocha, Filipe; Rocha, Júlio César; Moreira-Rosário, André; Vazão, Helena; Volovetska, Yuliya; Guimarães, João-Tiago; Pinto, Fausto J.
  • Freitas AT; HeartGenetics, Genetics and Biotechnology SA, Biocant Park, Cantanhede, Portugal.
  • Calhau C; INESC-ID, Instituto Superior Técnico, University of Lisbon, Lisboa, Portugal.
  • Antunes G; Nutrition and Metabolism, NOVA Medical School, Universidade Nova de Lisboa, Lisboa, Portugal.
  • Araújo B; CINTESIS - Center for Health Technology and Services Research, Porto, Portugal.
  • Bandeira M; HeartGenetics, Genetics and Biotechnology SA, Biocant Park, Cantanhede, Portugal.
  • Barreira S; Clinical Pathology Department, Centro Hospitalar Universitário de São João, Porto, Portugal.
  • Bazenga F; Rheumatology Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Centro Académico de Medicina de Lisboa, Lisboa, Portugal.
  • Braz S; Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, CAML, Lisboa, Portugal.
  • Caldeira D; Rheumatology Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Centro Académico de Medicina de Lisboa, Lisboa, Portugal.
  • Santos SCR; Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, CAML, Lisboa, Portugal.
  • Faria A; Clinical Pathology Department, Centro Hospitalar Universitário de São João, Porto, Portugal.
  • Faria D; Internal Medicine Department, Santa Maria Hospital, Centro Hospitalar Universitário Lisboa Norte, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal.
  • Fraga M; Centro Cardiovascular da Universidade de Lisboa (CCUL), CAML, Faculdade de Medicina, Universidade de Lisboa, 1649-028, Lisboa, Portugal.
  • Nogueira-Garcia B; Cardiology Department, Hospital Universitário de Santa Maria - CHULN, Lisboa, Portugal.
  • Gonçalves L; Centro Cardiovascular da Universidade de Lisboa (CCUL), CAML, Faculdade de Medicina, Universidade de Lisboa, 1649-028, Lisboa, Portugal.
  • Kovalchuk P; Nutrition and Metabolism, NOVA Medical School, Universidade Nova de Lisboa, Lisboa, Portugal.
  • Lacerda L; INESC-ID, Instituto Superior Técnico, University of Lisbon, Lisboa, Portugal.
  • Lopes H; Portuguese Infrastructure of Biological Data - BioData.pt, Lisbon, Portugal.
  • Luís D; Clinical Pathology Department, Hospital Santa Maria, Centro Hospitalar Universitário Lisboa Norte, EPE, Lisbon, Portugal.
  • Medeiros F; Cardiology Department, Hospital Universitário de Santa Maria - CHULN, Lisboa, Portugal.
  • Melo AMP; HeartGenetics, Genetics and Biotechnology SA, Biocant Park, Cantanhede, Portugal.
  • Melo-Cristino J; HeartGenetics, Genetics and Biotechnology SA, Biocant Park, Cantanhede, Portugal.
  • Miranda A; Clinical Pathology Department, Centro Hospitalar Universitário de São João, Porto, Portugal.
  • Pereira C; HeartGenetics, Genetics and Biotechnology SA, Biocant Park, Cantanhede, Portugal.
  • Pinto AT; HeartGenetics, Genetics and Biotechnology SA, Biocant Park, Cantanhede, Portugal.
  • Pinto J; Infectious Disease Department, Santa Maria Hospital - CHULN, Lisboa, Portugal.
  • Proença H; Portuguese Infrastructure of Biological Data - BioData.pt, Lisbon, Portugal.
  • Ramos A; Instituto Gulbenkian de Ciência, Oeiras, Portugal.
  • Rato JPR; Clinical Pathology Department, Hospital Santa Maria, Centro Hospitalar Universitário Lisboa Norte, EPE, Lisbon, Portugal.
  • Rocha F; Clinical Pathology Department, Hospital Santa Maria, Centro Hospitalar Universitário Lisboa Norte, EPE, Lisbon, Portugal.
  • Rocha JC; HeartGenetics, Genetics and Biotechnology SA, Biocant Park, Cantanhede, Portugal.
  • Moreira-Rosário A; Centro Cardiovascular da Universidade de Lisboa (CCUL), CAML, Faculdade de Medicina, Universidade de Lisboa, 1649-028, Lisboa, Portugal.
  • Vazão H; Clinical Pathology Department, Centro Hospitalar Universitário de São João, Porto, Portugal.
  • Volovetska Y; Clinical Pathology Department, Hospital Santa Maria, Centro Hospitalar Universitário Lisboa Norte, EPE, Lisbon, Portugal.
  • Guimarães JT; Clinical Pathology Department, Centro Hospitalar Universitário de São João, Porto, Portugal.
  • Pinto FJ; Biomedicine Department, Faculdade de Medicina, EPIUnit, Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.
Sci Rep ; 11(1): 20837, 2021 10 21.
Article in English | MEDLINE | ID: covidwho-1479820
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
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ABSTRACT
Vitamin D is a fundamental regulator of host defences by activating genes related to innate and adaptive immunity. Previous research shows a correlation between the levels of vitamin D in patients infected with SARS-CoV-2 and the degree of disease severity. This work investigates the impact of the genetic background related to vitamin D pathways on COVID-19 severity. For the first time, the Portuguese population was characterized regarding the prevalence of high impact variants in genes associated with the vitamin D pathways. This study enrolled 517 patients admitted to two tertiary Portuguese hospitals. The serum concentration of 25 (OH)D, was measured in the hospital at the time of patient admission. Genetic variants, 18 variants, in the genes AMDHD1, CYP2R1, CYP24A1, DHCR7, GC, SEC23A, and VDR were analysed. The results show that polymorphisms in the vitamin D binding protein encoded by the GC gene are related to the infection severity (p = 0.005). There is an association between vitamin D polygenic risk score and the serum concentration of 25 (OH)D (p = 0.04). There is an association between 25 (OH)D levels and the survival and fatal outcomes (p = 1.5e-4). The Portuguese population has a higher prevalence of the DHCR7 RS12785878 variant when compared with its prevalence in the European population (19% versus 10%). This study shows a genetic susceptibility for vitamin D deficiency that might explain higher severity degrees in COVID-19 patients. These results reinforce the relevance of personalized strategies in the context of viral diseases.Trial registration NCT04370808.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Polymorphism, Genetic / Vitamin D / Vitamin D Deficiency / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Topics: Variants Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-99952-z

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Polymorphism, Genetic / Vitamin D / Vitamin D Deficiency / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Topics: Variants Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-99952-z