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The Impact of SARS-CoV-2 Pandemic on Time to Primary, Secondary Resection and Adjuvant Intravesical Therapy in Patients with High-Risk Non-Muscle Invasive Bladder Cancer: A Retrospective Multi-Institutional Cohort Analysis.
Ferro, Matteo; Del Giudice, Francesco; Carrieri, Giuseppe; Busetto, Gian Maria; Cormio, Luigi; Hurle, Rodolfo; Contieri, Roberto; Arcaniolo, Davide; Sciarra, Alessandro; Maggi, Martina; Porpiglia, Francesco; Manfredi, Matteo; Fiori, Cristian; Antonelli, Alessandro; Tafuri, Alessandro; Bove, Pierluigi; Terrone, Carlo; Borghesi, Marco; Costantini, Elisabetta; Iliano, Ester; Montanari, Emanuele; Boeri, Luca; Russo, Giorgio Ivan; Madonia, Massimo; Tedde, Alessandro; Veccia, Alessandro; Simeone, Claudio; Liguori, Giovanni; Trombetta, Carlo; Brunocilla, Eugenio; Schiavina, Riccardo; Dal Moro, Fabrizio; Racioppi, Marco; Vartolomei, Mihai Dorin; Longo, Nicola; Spirito, Lorenzo; Crocetto, Felice; Cantiello, Francesco; Damiano, Rocco; Di Stasi, Savino M; Marchioni, Michele; Schips, Luigi; Parma, Paolo; Carmignani, Luca; Conti, Andrea; Soria, Francesco; Gontero, Paolo; Barone, Biagio; Deho, Federico; Zaffuto, Emanuele.
  • Ferro M; Department of Urology, IEO European Institute of Oncology, IRCCS, Via Ripamonti 435, 20141 Milan, Italy.
  • Del Giudice F; Department of Oncology and Hematology-Oncology, Università degli Studi di Milano, 20122 Milan, Italy.
  • Carrieri G; Department of Urology, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.
  • Busetto GM; Urology and Renal Transplantation Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.
  • Cormio L; Urology and Renal Transplantation Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.
  • Hurle R; Urology and Renal Transplantation Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.
  • Contieri R; Department of Urology, Humanitas Research Hospital, IRCCS, 20089 Milan, Italy.
  • Arcaniolo D; Department of Urology, Humanitas Research Hospital, IRCCS, 20089 Milan, Italy.
  • Sciarra A; Unit of Urology, Luigi Vanvitelli University of Campania, 80138 Naples, Italy.
  • Maggi M; Department of Urology, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.
  • Porpiglia F; Department of Urology, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.
  • Manfredi M; Department of Urology, San Luigi Gonzaga Hospital, University of Turin, Orbassano, 10043 Turin, Italy.
  • Fiori C; Department of Urology, San Luigi Gonzaga Hospital, University of Turin, Orbassano, 10043 Turin, Italy.
  • Antonelli A; Department of Urology, San Luigi Gonzaga Hospital, University of Turin, Orbassano, 10043 Turin, Italy.
  • Tafuri A; Department of Urology, Ospedale Civile Maggiore, Polo Chirurgico Confortini, University of Verona, 37126 Verona, Italy.
  • Bove P; Urology Unit, Azienda Ospedaliera Universitaria Integrata Verona, Piazzale Stefani 1, 37126 Verona, Italy.
  • Terrone C; Department of Urology, Ospedale Civile Maggiore, Polo Chirurgico Confortini, University of Verona, 37126 Verona, Italy.
  • Borghesi M; Urology Unit, Azienda Ospedaliera Universitaria Integrata Verona, Piazzale Stefani 1, 37126 Verona, Italy.
  • Costantini E; Department of Urology, San Carlo di Nancy Hospital, Via Aurelia 275, 00165 Rome, Italy.
  • Iliano E; Department of Urology, Policlinico San Martino Hospital, University of Genoa, 16132 Genova, Italy.
  • Montanari E; Department of Urology, Policlinico San Martino Hospital, University of Genoa, 16132 Genova, Italy.
  • Boeri L; Andrology and Urogynecology Clinic, Santa Maria Terni Hospital, University of Perugia, 05100 Terni, Italy.
  • Russo GI; Andrology and Urogynecology Clinic, Santa Maria Terni Hospital, University of Perugia, 05100 Terni, Italy.
  • Madonia M; Urology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
  • Tedde A; Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy.
  • Veccia A; Urology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
  • Simeone C; Department of Urology, University of Catania, 95124 Catania, Italy.
  • Liguori G; Urologic Clinic, Department of Clinical and Experimental Medicine, University of Sassari, 07100 Sassari, Italy.
  • Trombetta C; Urologic Clinic, Department of Clinical and Experimental Medicine, University of Sassari, 07100 Sassari, Italy.
  • Brunocilla E; Division of Urology, VCU Health System, Richmond, VA 23298, USA.
  • Schiavina R; Urology Unit, ASST Spedali Civili Hospital, 25133 Brescia, Italy.
  • Dal Moro F; Urology Unit, Department of Medical and Surgical Specialties, Radiological Science and Public Health, University of Brescia, 25121 Brescia, Italy.
  • Racioppi M; Urology Unit, Department of Medical and Surgical Specialties, Radiological Science and Public Health, University of Brescia, 25121 Brescia, Italy.
  • Vartolomei MD; Department of Urology, ASUITS, University of Trieste, 34149 Trieste, Italy.
  • Longo N; Department of Urology, ASUITS, University of Trieste, 34149 Trieste, Italy.
  • Spirito L; Department of Urology, University of Bologna, S-Orsola-Malpighi Hospital, 40138 Bologna, Italy.
  • Crocetto F; Department of Urology, University of Bologna, S-Orsola-Malpighi Hospital, 40138 Bologna, Italy.
  • Cantiello F; Urology Unit, Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, 35128 Padua, Italy.
  • Damiano R; Urology Clinic, A. Gemelli Hospital Foundation, Catholic University of the Sacred Heart, IRCCS, 00168 Rome, Italy.
  • Di Stasi SM; Urology Department, Medical University of Vienna, A-1090 Vienna, Austria.
  • Marchioni M; IOSUD, Universitatea de Medicina Farmacie Stiinte si Tehnologie "George Emil Palade" din Targu Mures, 540142 Mureș, Romania.
  • Schips L; Urology Unit, Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.
  • Parma P; Urology Unit, Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.
  • Carmignani L; Urology Unit, Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.
  • Conti A; Urology Unit, Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II, 80131 Naples, Italy.
  • Soria F; Department of Urology, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy.
  • Gontero P; Department of Surgery and Experimental Medicine, Tor Vergata University, 00133 Rome, Italy.
  • Barone B; Department of Medical, Oral and Biotechnological Sciences, Urology Unit, "SS. Annunziata" Hospital, G. d'Annunzio University of Chieti, 66100 Chieti, Italy.
  • Deho F; Department of Urology, ASL Abruzzo 2, 65017 Chieti, Italy.
  • Zaffuto E; Department of Medical, Oral and Biotechnological Sciences, Urology Unit, "SS. Annunziata" Hospital, G. d'Annunzio University of Chieti, 66100 Chieti, Italy.
Cancers (Basel) ; 13(21)2021 Oct 21.
Article in English | MEDLINE | ID: covidwho-1480597
ABSTRACT

BACKGROUND:

To investigate the impact of COVID-19 outbreak on the diagnosis and treatment of non-muscle invasive bladder cancer (NMIBC).

METHODS:

A retrospective analysis was performed using an Italian multi-institutional database of TURBT patients with high-risk urothelial NMIBC between January 2019 and February 2021, followed by Re-TURBT and/or adjuvant intravesical BCG.

RESULTS:

A total of 2591 patients from 27 institutions with primary TURBT were included. Of these, 1534 (59.2%) and 1056 (40.8%) underwent TURBT before and during the COVID-19 outbreak, respectively. Time between diagnosis and TURBT was significantly longer during the COVID-19 period (65 vs. 52 days, p = 0.002). One thousand and sixty-six patients (41.1%) received Re-TURBT, 604 (56.7%) during the pre-COVID-19. The median time to secondary resection was significantly longer during the COVID-19 period (55 vs. 48 days, p < 0.0001). A total of 977 patients underwent adjuvant intravesical therapy after primary or secondary resection, with a similar distribution across the two groups (n = 453, 86% vs. n = 388, 86.2%). However, the proportion of the patients who underwent maintenance significantly differed (79.5% vs. 60.4%, p < 0.0001).

CONCLUSIONS:

The COVID-19 pandemic represented an unprecedented challenge to our health system. Our study did not show significant differences in TURBT quality. However, a delay in treatment schedule and disease management was observed. Investigation of the oncological impacts of those differences should be advocated.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Year: 2021 Document Type: Article Affiliation country: Cancers13215276

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Year: 2021 Document Type: Article Affiliation country: Cancers13215276