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Comparison between Urine and Cervical High-Risk HPV Tests for Japanese Women with ASC-US.
Yamazaki, Hiroyuki; Wada, Tsuneyuki; Asano, Hiroshi; Fujita, Hiromasa; Okamoto, Kazuhira; Watari, Hidemichi.
  • Yamazaki H; Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine and Faculty of Medicine, Kita 15, Nishi 7, Kita-Ku, Sapporo 060-8638, Japan.
  • Wada T; Hokkaido Cancer Society, 1-15, Kita 26, Higashi 14, Higashi-Ku, Sapporo 065-0026, Japan.
  • Asano H; Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine and Faculty of Medicine, Kita 15, Nishi 7, Kita-Ku, Sapporo 060-8638, Japan.
  • Fujita H; Hokkaido Cancer Society, 1-15, Kita 26, Higashi 14, Higashi-Ku, Sapporo 065-0026, Japan.
  • Okamoto K; Hokkaido Cancer Society, 1-15, Kita 26, Higashi 14, Higashi-Ku, Sapporo 065-0026, Japan.
  • Watari H; Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine and Faculty of Medicine, Kita 15, Nishi 7, Kita-Ku, Sapporo 060-8638, Japan.
Diagnostics (Basel) ; 11(10)2021 Oct 14.
Article in English | MEDLINE | ID: covidwho-1480627
ABSTRACT
Most uterine cervical cancers are caused by the persistent infection of the high-risk human papillomavirus (hrHPV). Thus, the hrHPV-DNA test, which examines specimens from the cervix, is the standard screening method as well as cytology in western countries. Urine sampling for the hrHPV-DNA test would be easier and help improving screening rates. This study prospectively investigated the concordance between urine and cervical hrHPV tests for patients with atypical squamous cells of undetermined significance (ASC-US) in cervical cytology. We recruited 338 women with the cytologic diagnosis of ASC-US and performed hrHPV-DNA tests to both samples from the uterine cervix and first void urine, using the Cobas 4800 system. In all hrHPV genotypes, the simple concordance rate was 90.8% (307/338) and the Kappa statistic value was 0.765, which shows substantial concordance. The positive concordance rate was 70.5% (74/105), which was the rate excluding women who had negative results in both tests. When limited to types 16 and 18, the simple concordance rate was 98.8% (334/338), and the Kappa statistical value was calculated to be 0.840, which showed almost perfect concordance. The positive concordance rate resulted in 81.8% (18/22). We conclude that the urine hrHPV-DNA test could substitute the cervical test in women with ASC-US.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Diagnostics11101895

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Diagnostics11101895