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Ultramicronized Palmitoylethanolamide in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation.
D'Amico, Ramona; Monaco, Francesco; Siracusa, Rosalba; Cordaro, Marika; Fusco, Roberta; Peritore, Alessio Filippo; Gugliandolo, Enrico; Crupi, Rosalia; Cuzzocrea, Salvatore; Di Paola, Rosanna; Impellizzeri, Daniela; Genovese, Tiziana.
  • D'Amico R; Department of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, 98166 Messina, Italy.
  • Monaco F; Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98166 Messina, Italy.
  • Siracusa R; Department of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, 98166 Messina, Italy.
  • Cordaro M; Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98166 Messina, Italy.
  • Fusco R; Department of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, 98166 Messina, Italy.
  • Peritore AF; Department of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, 98166 Messina, Italy.
  • Gugliandolo E; Department of Veterinary Science, University of Messina, 98166 Messina, Italy.
  • Crupi R; Department of Veterinary Science, University of Messina, 98166 Messina, Italy.
  • Cuzzocrea S; Department of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, 98166 Messina, Italy.
  • Di Paola R; Department of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, 98166 Messina, Italy.
  • Impellizzeri D; Department of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, 98166 Messina, Italy.
  • Genovese T; Department of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, 98166 Messina, Italy.
Int J Mol Sci ; 22(21)2021 Oct 21.
Article in English | MEDLINE | ID: covidwho-1480798
ABSTRACT
Disseminated intravascular coagulation (DIC) is a severe condition characterized by the systemic formation of microthrombi complicated with bleeding tendency and organ dysfunction. In the last years, it represents one of the most frequent consequences of coronavirus disease 2019 (COVID-19). The pathogenesis of DIC is complex, with cross-talk between the coagulant and inflammatory pathways. The objective of this study is to investigate the anti-inflammatory action of ultramicronized palmitoylethanolamide (um-PEA) in a lipopolysaccharide (LPS)-induced DIC model in rats. Experimental DIC was induced by continual infusion of LPS (30 mg/kg) for 4 h through the tail vein. Um-PEA (30 mg/kg) was given orally 30 min before and 1 h after the start of intravenous infusion of LPS. Results showed that um-PEA reduced alteration of coagulation markers, as well as proinflammatory cytokine release in plasma and lung samples, induced by LPS infusion. Furthermore, um-PEA also has the effect of preventing the formation of fibrin deposition and lung damage. Moreover, um-PEA was able to reduce the number of mast cells (MCs) and the release of its serine proteases, which are also necessary for SARS-CoV-2 infection. These results suggest that um-PEA could be considered as a potential therapeutic approach in the management of DIC and in clinical implications associated to coagulopathy and lung dysfunction, such as COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Palmitic Acids / Blood Coagulation Disorders / Sepsis / Disseminated Intravascular Coagulation / Ethanolamines / Amides Type of study: Etiology study / Randomized controlled trials Topics: Long Covid Limits: Animals Language: English Year: 2021 Document Type: Article Affiliation country: Ijms222111388

Full text: Available Collection: International databases Database: MEDLINE Main subject: Palmitic Acids / Blood Coagulation Disorders / Sepsis / Disseminated Intravascular Coagulation / Ethanolamines / Amides Type of study: Etiology study / Randomized controlled trials Topics: Long Covid Limits: Animals Language: English Year: 2021 Document Type: Article Affiliation country: Ijms222111388