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ACE2 and Innate Immunity in the Regulation of SARS-CoV-2-Induced Acute Lung Injury: A Review.
Qu, Lihua; Chen, Chao; Yin, Tong; Fang, Qian; Hong, Zizhan; Zhou, Rui; Tang, Hongbin; Dong, Huifen.
  • Qu L; Department of Pathogenic Biology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
  • Chen C; School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210013, China.
  • Yin T; Department of Pathogenic Biology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
  • Fang Q; Department of Pathogenic Biology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
  • Hong Z; Department of Pathogenic Biology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
  • Zhou R; Department of Pathogenic Biology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
  • Tang H; Center for Animal Experiment, State Key Laboratory of Virology, Wuhan University, Wuhan 430071, China.
  • Dong H; Department of Pathogenic Biology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
Int J Mol Sci ; 22(21)2021 Oct 25.
Article in English | MEDLINE | ID: covidwho-1480801
ABSTRACT
Despite the protracted battle against coronavirus acute respiratory infection (COVID-19) and the rapid evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), no specific and effective drugs have to date been reported. Angiotensin-converting enzyme 2 (ACE2) is a zinc metalloproteinase and a critical modulator of the renin-angiotensin system (RAS). In addition, ACE2 has anti-inflammatory and antifibrosis functions. ACE has become widely known in the past decade as it has been identified as the primary receptor for SARS-CoV and SARS-CoV-2, being closely associated with their infection. SARS-CoV-2 primarily targets the lung, which induces a cytokine storm by infecting alveolar cells, resulting in tissue damage and eventually severe acute respiratory syndrome. In the lung, innate immunity acts as a critical line of defense against pathogens, including SARS-CoV-2. This review aims to summarize the regulation of ACE2, and lung host cells resist SARS-CoV-2 invasion by activating innate immunity response. Finally, we discuss ACE2 as a therapeutic target, providing reference and enlightenment for the clinical treatment of COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Acute Lung Injury / Angiotensin-Converting Enzyme 2 / SARS-CoV-2 / Immunity, Innate Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms222111483

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Acute Lung Injury / Angiotensin-Converting Enzyme 2 / SARS-CoV-2 / Immunity, Innate Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms222111483