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Pfizer-BioNTech and Sinopharm: A Comparative Study on Post-Vaccination Antibody Titers.
Alqassieh, Rami; Suleiman, Aiman; Abu-Halaweh, Sami; Santarisi, Abeer; Shatnawi, Omar; Shdaifat, Lara; Tarifi, Amjed; Al-Tamimi, Mohammad; Al-Shudifat, Abdel-Ellah; Alsmadi, Heba; Al Sharqawi, Ahmed; Alnawaiseh, Hadeel; Anasweh, Yara; Domaidah, Farah Abo; Jaber, Haneen Abu; Al-Zarir, Mohammad Rashid; Bsisu, Isam.
  • Alqassieh R; Department of General and Specialized Surgery, Faculty of Medicine, The Hashemite University, Zarqa 13133, Jordan.
  • Suleiman A; Beth Israel Deaconess Medical Center, Anesthesia and Intensive Care Department, Harvard Medical School, Boston, MA 02215, USA.
  • Abu-Halaweh S; Department of Anesthesia and Intensive Care, School of Medicine, The University of Jordan, Amman 11942, Jordan.
  • Santarisi A; Department of Emergency Medicine and Accidents, School of Medicine, The University of Jordan, Amman 11942, Jordan.
  • Shatnawi O; Department of Cancer Biology, Wake Forest School of Medicine and Wake Forest Baptist Health, Winston-Salem, NC 27157, USA.
  • Shdaifat L; School of Medicine, Mutah University, Karak 61710, Jordan.
  • Tarifi A; Department of General and Specialized Surgery, Faculty of Medicine, The Hashemite University, Zarqa 13133, Jordan.
  • Al-Tamimi M; Faculty of Medicine, The Hashemite University, Zarqa 13133, Jordan.
  • Al-Shudifat AE; Faculty of Medicine, The Hashemite University, Zarqa 13133, Jordan.
  • Alsmadi H; Department of Anesthesia and Intensive Care, School of Medicine, The University of Jordan, Amman 11942, Jordan.
  • Al Sharqawi A; Department of Anesthesia and Intensive Care, School of Medicine, The University of Jordan, Amman 11942, Jordan.
  • Alnawaiseh H; Department of Anesthesia and Intensive Care, School of Medicine, The University of Jordan, Amman 11942, Jordan.
  • Anasweh Y; Department of Anesthesia and Intensive Care, School of Medicine, The University of Jordan, Amman 11942, Jordan.
  • Domaidah FA; Department of Anesthesia and Intensive Care, School of Medicine, The University of Jordan, Amman 11942, Jordan.
  • Jaber HA; Department of Anesthesia and Intensive Care, School of Medicine, The University of Jordan, Amman 11942, Jordan.
  • Al-Zarir MR; Department of Anesthesia and Intensive Care, School of Medicine, The University of Jordan, Amman 11942, Jordan.
  • Bsisu I; Department of Anesthesia and Intensive Care, School of Medicine, The University of Jordan, Amman 11942, Jordan.
Vaccines (Basel) ; 9(11)2021 Oct 21.
Article in English | MEDLINE | ID: covidwho-1481046
ABSTRACT
COVID-19 (coronavirus disease 2019) vaccines induce immunity through different mechanisms. The aim of this study is to compare the titers of specific antibodies in subjects vaccinated with either the Pfizer-BioNTech COVID-19 vaccine or the Sinopharm vaccine. This prospective observational cohort included Jordanian adults vaccinated with two doses, 21 days apart, of either of the two aforementioned vaccines. Titers were collected 6 weeks after the administration of the second dose. Overall, 288 participants were included, of which 141 were administered the Pfizer-BioNTech vaccine, while 147 were administered the Sinopharm vaccine. Remarkably, 140 (99.3%) of the Pfizer-BioNTech vaccine recipients had positive IgG titers, while 126 (85.7%) of Sinopharm recipients had positive IgG (p < 0.001). The mean titer for IgG among Pfizer-BioNTech recipients was 515.5 ± 1143.5 BAU/mL, compared to 170.0 ± 230.0 BAU/mL among Sinopharm subjects (p < 0.001). Multivariable regression analysis showed that the Pfizer-BioNTech vaccine positively correlated with positive IgG titers (OR 25.25; 95% CI 3.25-196.15; p = 0.002), compared with a negative effect of cardiovascular diseases (OR 0.33; 95% CI 0.11-0.99; p = 0.48) on IgG titers. In conclusion, fully vaccinated recipients of the Pfizer-BioNTech vaccine had superior quantitative efficiency compared to Sinopharm recipients. A booster dose is supported for Sinopharm recipients, or those with chronic immunosuppressive diseases.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Topics: Vaccines Language: English Year: 2021 Document Type: Article Affiliation country: Vaccines9111223

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Topics: Vaccines Language: English Year: 2021 Document Type: Article Affiliation country: Vaccines9111223