Thrombotic thrombocytopenia following ChAdOx1 nCov-19 vaccination
Acute Medicine
; 20(3):223-226, 2021.
Article
in English
| MEDLINE | ID: covidwho-1481602
ABSTRACT
Serious thromboembolic events with concurrent thrombocytopenia, sometimes accompanied by bleeding, have occurred very rarely following administration of the ChAdOx1 nCoV-19 vaccine. We report the case of a 59-year-old male with an unremarkable medical history who presented to the emergency department with increasing breathlessness five days after receiving the first dose of ChAdOx1 nCov-19. The patient's blood results showed mild thrombocytopenia and a very high D-dimer, and a pulmonary embolism was confirmed through a CT pulmonary angiogram, which led to a provisional diagnosis of vaccine-induced immune thrombotic thrombocytopenia. The condition was then treated with immunoglobulin and intravenous argatroban in line with the guidance from the Expert Haematology Panel focussed on Vaccine-induced Thrombosis and Thrombocytopenia before conversion to apixaban.
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Collection:
Databases of international organizations
Database:
MEDLINE
Topics:
Vaccines
Language:
English
Journal:
Acute Medicine
Year:
2021
Document Type:
Article
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