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Real-world use of ecco2r to correct respiratory acidosis: Analysis of the hemolung registry
ASAIO Journal ; 67(SUPPL 3):14, 2021.
Article in English | EMBASE | ID: covidwho-1481655
ABSTRACT
Extracorporeal CO2 removal (ECCO2R) can benefit critically ill patients with hypercapnic acidosis by correcting pH and PaCO2. The Hemolung RAS (ALung Technologies) has provided ECCO2R therapy to over 1100 patients. The voluntary Hemolung Registry Program collects safety and benefit data from commercial use, US Emergency Use, and US Emergency Use Authorization therapies. 176 Hemolung patients were analyzed to evaluate the benefits and safety of Hemolung therapy. Multiple primary diagnoses were represented 31% ARDS, 22% COPD exacerbation, 32% COVID-19, and 15% Other. Median duration of Hemolung therapy was 6.0 days. Median CO2 removal by the Hemolung during the first day of therapy was 88 mL/min and resulted in a concomitant correction of pH from a median of 7.20 to 7.35 (p<0.001) and median PaCO2 correction of 81.7 to 57.0 mmHg (p<0.001). Correction of respiratory acidosis was independent of primary diagnosis, age, and BMI. 69% (112/162) of patients survived to de-cannulation. 86% (19/22) of patients failing NIV avoided intubation. There were no unanticipated complications, and the majority of adverse events did not require medical intervention or discontinuation of Hemolung therapy. 3 deaths associated with Hemolung therapy occurred. To date, this is the largest analysis of ECCO2R to treat a diverse population of hypercapnic respiratory failure patients. The results demonstrate significant physiologic benefit from Hemolung therapy, and literature-based evidence suggests this benefit may result in improved outcomes, however data from RCTs are needed to determine whether these physiologic benefits translate to improved outcomes compared to current standard of care.
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Collection: Databases of international organizations Database: EMBASE Language: English Journal: ASAIO Journal Year: 2021 Document Type: Article

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Collection: Databases of international organizations Database: EMBASE Language: English Journal: ASAIO Journal Year: 2021 Document Type: Article