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Anti-SARS-CoV-2 and Autoantibody Profiles in the Cerebrospinal Fluid of 3 Teenaged Patients With COVID-19 and Subacute Neuropsychiatric Symptoms.
Bartley, Christopher M; Johns, Claire; Ngo, Thomas T; Dandekar, Ravi; Loudermilk, Rita L; Alvarenga, Bonny D; Hawes, Isobel A; Zamecnik, Colin R; Zorn, Kelsey C; Alexander, Jessa R; Wapniarski, Anne E; DeRisi, Joseph L; Francisco, Carla; Nash, Kendall B; Wietstock, Sharon O; Pleasure, Samuel J; Wilson, Michael R.
  • Bartley CM; Hanna H. Gray Fellow, Howard Hughes Medical Institute, Chevy Chase, Maryland.
  • Johns C; Weill Institute for Neurosciences, University of California, San Francisco.
  • Ngo TT; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco.
  • Dandekar R; Department of Pediatrics, University of California, San Francisco.
  • Loudermilk RL; Weill Institute for Neurosciences, University of California, San Francisco.
  • Alvarenga BD; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco.
  • Hawes IA; Weill Institute for Neurosciences, University of California, San Francisco.
  • Zamecnik CR; Department of Neurology, University of California, San Francisco.
  • Zorn KC; Weill Institute for Neurosciences, University of California, San Francisco.
  • Alexander JR; Department of Neurology, University of California, San Francisco.
  • Wapniarski AE; Weill Institute for Neurosciences, University of California, San Francisco.
  • DeRisi JL; Department of Neurology, University of California, San Francisco.
  • Francisco C; Weill Institute for Neurosciences, University of California, San Francisco.
  • Nash KB; Department of Neurology, University of California, San Francisco.
  • Wietstock SO; Biomedical Sciences Graduate Program, University of California, San Francisco.
  • Pleasure SJ; Weill Institute for Neurosciences, University of California, San Francisco.
  • Wilson MR; Department of Neurology, University of California, San Francisco.
JAMA Neurol ; 78(12): 1503-1509, 2021 12 01.
Article in English | MEDLINE | ID: covidwho-1482083
ABSTRACT
Importance Neuropsychiatric manifestations of COVID-19 have been reported in the pediatric population.

Objective:

To determine whether anti-SARS-CoV-2 and autoreactive antibodies are present in the cerebrospinal fluid (CSF) of pediatric patients with COVID-19 and subacute neuropsychiatric dysfunction. Design, Setting, and

Participants:

This case series includes 3 patients with recent SARS-CoV-2 infection as confirmed by reverse transcriptase-polymerase chain reaction or IgG serology with recent exposure history who were hospitalized at the University of California, San Francisco Benioff Children's Hospital and for whom a neurology consultation was requested over a 5-month period in 2020. During this period, 18 total children were hospitalized and tested positive for acute SARS-CoV-2 infection by reverse transcriptase-polymerase chain reaction or rapid antigen test. Main Outcomes and

Measures:

Detection and characterization of CSF anti-SARS-CoV-2 IgG and antineural antibodies.

Results:

Of 3 included teenaged patients, 2 patients had intrathecal anti-SARS-CoV-2 antibodies. CSF IgG from these 2 patients also indicated antineural autoantibodies on anatomic immunostaining. Autoantibodies targeting transcription factor 4 (TCF4) in 1 patient who appeared to have a robust response to immunotherapy were also validated. Conclusions and Relevance Pediatric patients with COVID-19 and prominent subacute neuropsychiatric symptoms, ranging from severe anxiety to delusional psychosis, may have anti-SARS-CoV-2 and antineural antibodies in their CSF and may respond to immunotherapy.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Autoantibodies / COVID-19 / Mental Disorders / Antibodies, Viral / Nervous System Diseases Type of study: Case report / Prognostic study / Qualitative research Topics: Long Covid Limits: Adolescent / Animals / Female / Humans / Male Language: English Journal: JAMA Neurol Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Autoantibodies / COVID-19 / Mental Disorders / Antibodies, Viral / Nervous System Diseases Type of study: Case report / Prognostic study / Qualitative research Topics: Long Covid Limits: Adolescent / Animals / Female / Humans / Male Language: English Journal: JAMA Neurol Year: 2021 Document Type: Article