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Liver function as a predictor of mortality in COVID-19: A retrospective study.
Salik, Fikret; Uzundere, Osman; Biçak, Mustafa; Akelma, Hakan; Akgündüz, Mesut; Korhan, Zeki; Kandemir, Deniz; Kaçar, Cem Kivilcim.
  • Salik F; Gazi Yasargil Training and Research Hospital, Anesthesiology and Reanimation Clinic, Diyarbakir 21010, Turkey. Electronic address: fikretsalik@gmail.com.
  • Uzundere O; Gazi Yasargil Training and Research Hospital, Anesthesiology and Reanimation Clinic, Diyarbakir 21010, Turkey. Electronic address: osmanuzundere@gmail.com.
  • Biçak M; Gazi Yasargil Training and Research Hospital, Anesthesiology and Reanimation Clinic, Diyarbakir 21010, Turkey. Electronic address: drmustafabicak@gmail.com.
  • Akelma H; Gazi Yasargil Training and Research Hospital, Anesthesiology and Reanimation Clinic, Diyarbakir 21010, Turkey. Electronic address: hakanakelma@hotmail.com.
  • Akgündüz M; Gazi Yasargil Training and Research Hospital, Anesthesiology and Reanimation Clinic, Diyarbakir 21010, Turkey. Electronic address: maentri@outlook.com.
  • Korhan Z; Gazi Yasargil Training and Research Hospital, Anesthesiology and Reanimation Clinic, Diyarbakir 21010, Turkey. Electronic address: korhanzeki@gmail.com.
  • Kandemir D; Gazi Yasargil Training and Research Hospital, Anesthesiology and Reanimation Clinic, Diyarbakir 21010, Turkey. Electronic address: denizkande@gmail.com.
  • Kaçar CK; Gazi Yasargil Training and Research Hospital, Anesthesiology and Reanimation Clinic, Diyarbakir 21010, Turkey. Electronic address: cem.kacar@hotmail.com.
Ann Hepatol ; 26: 100553, 2021 12.
Article in English | MEDLINE | ID: covidwho-1482445
ABSTRACT
INTRODUCTION AND

OBJECTIVES:

In many studies, varying degrees of liver damage have been reported in more than half of the COVID-19 patients. The aim of this study is to determine the effect of liver biochemical parameters abnormality on mortality in critical COVID-19 patients who have been followed in the ICU since the beginning of the pandemic process. MATERIALS AND

METHODS:

In this study 533 critical patients who admitted to the ICU due to COVID-19 were included. The patients were divided into three groups according to their ALT, AST, and total bilirubin levels at their admission to the ICU. Group 1 was formed of patients with normal liver biochemical parameters values; Group 2 was formed of patients with liver biochemical parameters abnormality; Group 3 was formed of patients with liver injury.

RESULTS:

353 (66.2%) of all patients died. Neutrophil, aPTT, CRP, LDH, CK, ALT, AST, bilirubin, procalcitonin and ferritin values in Group 2 and Group 3 were found to be statistically significantly higher than Group 1. It was detected that the days of stay in ICU of the patients in Group 1 was statistically significantly longer than others group. It was found that the patients in Groups 2 and 3 had higher total, 7-day, and 28-day mortality rates than expected.

CONCLUSIONS:

The study showed that liver disfunction was associated with higher mortality and shorter ICU occupation time.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Liver / Liver Diseases / Liver Function Tests Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Ann Hepatol Journal subject: Gastroenterology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Liver / Liver Diseases / Liver Function Tests Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Ann Hepatol Journal subject: Gastroenterology Year: 2021 Document Type: Article