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Hydroxichloroquine for COVID-19 infection: Do we have a final word after one year?
Di Castelnuovo, Augusto; Costanzo, Simona; Gialluisi, Alessandro; Iacoviello, Licia; de Gaetano, Giovanni.
  • Di Castelnuovo A; Mediterranea Cardiocentro, Napoli, Italy. Electronic address: dicastel@ngi.it.
  • Costanzo S; Department of Epidemiology and Prevention, IRCCS Neuromed, Via dell'Elettronica, Pozzilli, Isernia 86077, Italy.
  • Gialluisi A; Department of Epidemiology and Prevention, IRCCS Neuromed, Via dell'Elettronica, Pozzilli, Isernia 86077, Italy.
  • Iacoviello L; Department of Epidemiology and Prevention, IRCCS Neuromed, Via dell'Elettronica, Pozzilli, Isernia 86077, Italy; Department of Medicine and Surgery, University of Insubria, Varese, Italy.
  • de Gaetano G; Department of Epidemiology and Prevention, IRCCS Neuromed, Via dell'Elettronica, Pozzilli, Isernia 86077, Italy.
Eur J Intern Med ; 94: 4-5, 2021 12.
Article in English | MEDLINE | ID: covidwho-1482562
ABSTRACT
The results presently available from randomised clinical trials and their meta-analysis indicate that Hydroxychloroquine is not associated in COVID-19 patients with either decreased mortality or clinical worsening. Thus, the use of Hydroxychloroquine in COVID-19 patients cannot at present be encouraged. However, the hypothesis that Hydroxychloroquine might have a beneficial role in subgroups of patients at low risk and/or when used at low dosage (≤ 400 mg/day) deserves to be tested in large, well designed randomised clinical trials.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials / Reviews Limits: Humans Language: English Journal: Eur J Intern Med Journal subject: Internal Medicine Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials / Reviews Limits: Humans Language: English Journal: Eur J Intern Med Journal subject: Internal Medicine Year: 2021 Document Type: Article