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Autoimmune hepatitis after COVID-19 vaccine - more than a coincidence.
Garrido, Isabel; Lopes, Susana; Simões, Manuel Sobrinho; Liberal, Rodrigo; Lopes, Joanne; Carneiro, Fátima; Macedo, Guilherme.
  • Garrido I; Gastroenterology and Hepatology Department, Centro Hospitalar e Universitário de São João, Porto, Portugal; World Gastroenterology Organization (WGO) Porto Training Center, Porto, Portugal. Electronic address: isabelmng@hotmail.com.
  • Lopes S; Gastroenterology and Hepatology Department, Centro Hospitalar e Universitário de São João, Porto, Portugal; World Gastroenterology Organization (WGO) Porto Training Center, Porto, Portugal.
  • Simões MS; Department of Clinical Hematology, Centro Hospitalar Universitário de São João, Porto, Portugal.
  • Liberal R; Gastroenterology and Hepatology Department, Centro Hospitalar e Universitário de São João, Porto, Portugal; World Gastroenterology Organization (WGO) Porto Training Center, Porto, Portugal.
  • Lopes J; Pathology Department, Centro Hospitalar Universitário de São João, Porto, Portugal.
  • Carneiro F; Pathology Department, Centro Hospitalar Universitário de São João, Porto, Portugal.
  • Macedo G; Gastroenterology and Hepatology Department, Centro Hospitalar e Universitário de São João, Porto, Portugal; World Gastroenterology Organization (WGO) Porto Training Center, Porto, Portugal.
J Autoimmun ; 125: 102741, 2021 12.
Article in English | MEDLINE | ID: covidwho-1482678
ABSTRACT
The COVID-19 pandemic is still raging across the world and vaccination is expected to lead us out of this pandemic. Although the efficacy of the vaccines is beyond doubt, safety still remains a concern. We report a case of a 65-year-old woman who experienced acute severe autoimmune hepatitis two weeks after receiving the first dose of Moderna-COVID-19 vaccine. Serum immunoglobulin G was elevated and antinuclear antibody was positive (1100, speckled pattern). Liver histology showed a marked expansion of the portal tracts, severe interface hepatitis and multiple confluent foci of lobular necrosis. She started treatment with prednisolone, with a favorable clinical and analytical evolution. Some recent reports have been suggested that COVID-19 vaccination can lead to the development of autoimmune diseases. It is speculated that the vaccine can disturb self-tolerance and trigger autoimmune responses through cross-reactivity with host cells. Therefore, healthcare providers must remain vigilant during mass COVID-19 vaccination.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccination / Hepatitis, Autoimmune / COVID-19 / BNT162 Vaccine / Jaundice Type of study: Case report / Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Female / Humans / Middle aged Language: English Journal: J Autoimmun Journal subject: Allergy and Immunology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccination / Hepatitis, Autoimmune / COVID-19 / BNT162 Vaccine / Jaundice Type of study: Case report / Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Female / Humans / Middle aged Language: English Journal: J Autoimmun Journal subject: Allergy and Immunology Year: 2021 Document Type: Article