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WHO International Standard for evaluation of the antibody response to COVID-19 vaccines: call for urgent action by the scientific community.
Knezevic, Ivana; Mattiuzzo, Giada; Page, Mark; Minor, Philip; Griffiths, Elwyn; Nuebling, Micha; Moorthy, Vasee.
  • Knezevic I; Department of Health Products Policy and Standards, Access to Medicines and Health Products, World Health Organization, Geneva, Switzerland.
  • Mattiuzzo G; National Institute for Biological Standards and Control, Potters Bar, UK.
  • Page M; National Institute for Biological Standards and Control, Potters Bar, UK.
  • Minor P; St Albans, UK.
  • Griffiths E; Kingston upon Thames, UK.
  • Nuebling M; Paul-Ehrlich-Institut, Langen, Germany.
  • Moorthy V; Research for Health Department, Science Division, World Health Organization, Geneva, Switzerland.
Lancet Microbe ; 3(3): e235-e240, 2022 03.
Article in English | MEDLINE | ID: covidwho-1483037
ABSTRACT
The first WHO International Standard and International Reference Panel for anti-SARS-CoV-2 immunoglobulin were established by the WHO Expert Committee on Biological Standardization in December, 2020. The WHO International Antibody Standards are intended to serve as global reference reagents, against which national reference preparations or secondary standards can be calibrated. Calibration will facilitate comparison of results of assays (eg, of the neutralising antibody response to candidate COVID-19 vaccines) conducted in different countries. Use of these standards is expected to contribute to better understanding of the immune response, and particularly of the correlates of protection. This Personal View provides some technical details of the WHO Antibody Standards for SARS-CoV-2, focusing specifically on the use of these standards for the evaluation of the immune response to COVID-19 vaccines, rather than other applications (eg, diagnostic or therapeutic). The explanation with regard to why rapid adoption of the standards is crucial is also included, as well as how funders, journals, regulators, and ethics committees could drive adoption in the interest of public health.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Experimental Studies Topics: Vaccines Limits: Humans Language: English Journal: Lancet Microbe Year: 2022 Document Type: Article Affiliation country: S2666-5247(21)00266-4

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Experimental Studies Topics: Vaccines Limits: Humans Language: English Journal: Lancet Microbe Year: 2022 Document Type: Article Affiliation country: S2666-5247(21)00266-4