Your browser doesn't support javascript.
Organic Photo-antimicrobials: Principles, Molecule Design, and Applications.
Ran, Bei; Wang, Zuokai; Cai, Wenlin; Ran, Lei; Xia, Wenxi; Liu, Weijian; Peng, Xiaojun.
  • Ran B; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China.
  • Wang Z; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China.
  • Cai W; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China.
  • Ran L; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China.
  • Xia W; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China.
  • Liu W; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China.
  • Peng X; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China.
J Am Chem Soc ; 143(43): 17891-17909, 2021 11 03.
Article in English | MEDLINE | ID: covidwho-1483091
ABSTRACT
The emergence of multi-drug-resistant pathogens threatens the healthcare systems world-wide. Recent advances in phototherapy (PT) approaches mediated by photo-antimicrobials (PAMs) provide new opportunities for the current serious antibiotic resistance. During the PT treatment, reactive oxygen species or heat produced by PAMs would react with the cell membrane, consequently leaking cytoplasm components and effectively eradicating different pathogens like bacteria, fungi, viruses, and even parasites. This Perspective will concentrate on the development of different organic photo-antimicrobials (OPAMs) and their application as practical therapeutic agents into therapy for local infections, wound dressings, and removal of biofilms from medical devices. We also discuss how to design highly efficient OPAMs by modifying the chemical structure or conjugating with a targeting component. Moreover, this Perspective provides a discussion of the general challenges and direction for OPAMs and what further needs to be done. It is hoped that through this overview, OPAMs can prosper and will be more widely used for microbial infections in the future, especially at a time when the global COVID-19 epidemic is getting more serious.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Phototherapy / Drug Design / Anti-Infective Agents Limits: Animals Language: English Journal: J Am Chem Soc Year: 2021 Document Type: Article Affiliation country: Jacs.1c08679

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Phototherapy / Drug Design / Anti-Infective Agents Limits: Animals Language: English Journal: J Am Chem Soc Year: 2021 Document Type: Article Affiliation country: Jacs.1c08679