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Treatment for COVID-19-a cohort study from Northern Italy.
Guglielmetti, Lorenzo; Aschieri, Daniela; Kontsevaya, Irina; Calabrese, Francesco; Donisi, Alessandra; Faggi, Alberto; Ferrante, Patrizia; Fronti, Elisa; Gerna, Laura; Leoni, Maria Cristina; Paolillo, Franco; Ratti, Giovanna; Ruggieri, Alessandro; Sacchini, Daria; Scotti, Marta; Valdatta, Caterina; Stabile, Marco; Taliani, Gloria; Codeluppi, Mauro.
  • Guglielmetti L; Sorbonne Université, INSERM, U1135, Centre d'Immunologie et des Maladies Infectieuses, Cimi-Paris, équipe 13, Paris, France. lorenzo.guglielmetti@aphp.fr.
  • Aschieri D; APHP, Groupe Hospitalier Universitaire Sorbonne Université, Hôpital Pitié-Salpêtrière, Centre National de Référence Des Mycobactéries Et de La Résistance Des Mycobactéries Aux Antituberculeux, Paris, France. lorenzo.guglielmetti@aphp.fr.
  • Kontsevaya I; Infectious Diseases Unit, Guglielmo da Saliceto Hospital, Piacenza, Italy. lorenzo.guglielmetti@aphp.fr.
  • Calabrese F; Cardiology Unit, Castel San Giovanni Hospital, Piacenza, Italy.
  • Donisi A; Research Center Borstel, Borstel, Germany.
  • Faggi A; German Center for Infection Research, Hamburg-Lübeck-Borstel-Riems, Borstel, Germany.
  • Ferrante P; International Health/Infectious Diseases, University of Lübeck, Lübeck, Germany.
  • Fronti E; Infectious Diseases Unit, Guglielmo da Saliceto Hospital, Piacenza, Italy.
  • Gerna L; Migration Health Unit, Primary Health Care Department, Guglielmo da Saliceto Hospital, Piacenza, Italy.
  • Leoni MC; Infectious Diseases Unit, Guglielmo da Saliceto Hospital, Piacenza, Italy.
  • Paolillo F; Infectious Diseases Unit, Guglielmo da Saliceto Hospital, Piacenza, Italy.
  • Ratti G; Institute for Cross-Disciplinary Physics and Complex Systems IFISC (UIB-CSIC), Campus Universitat Illes Balears, 07122, Palma de Mallorca, Spain.
  • Ruggieri A; Infectious Diseases Unit, Guglielmo da Saliceto Hospital, Piacenza, Italy.
  • Sacchini D; Infectious Diseases Unit, Guglielmo da Saliceto Hospital, Piacenza, Italy.
  • Scotti M; Infectious Diseases Unit, Guglielmo da Saliceto Hospital, Piacenza, Italy.
  • Valdatta C; Infectious Diseases Unit, Guglielmo da Saliceto Hospital, Piacenza, Italy.
  • Stabile M; Infectious Diseases Unit, Guglielmo da Saliceto Hospital, Piacenza, Italy.
  • Taliani G; Infectious Diseases Unit, Guglielmo da Saliceto Hospital, Piacenza, Italy.
  • Codeluppi M; Infectious Diseases Unit, Guglielmo da Saliceto Hospital, Piacenza, Italy.
Sci Rep ; 11(1): 20964, 2021 10 25.
Article in English | MEDLINE | ID: covidwho-1483147
ABSTRACT
Multicentre, retrospective cohort study with multivariable Cox proportional-hazards modelling and survival-time inverse-probability-weighting, evaluating the impact of different treatments on survival of proven COVID-19 patients admitted to two Hospitals in the province of Piacenza, Italy. Use of tocilizumab and of high doses of low molecular weight heparin, but not of antivirals (either alone or in combination), azithromycin, and any corticosteroid, was independently associated with lower mortality. Our results support further clinical evaluation of high doses of low molecular weight heparin and tocilizumab as COVID-19 therapeutics.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Heparin / Antibodies, Monoclonal, Humanized / COVID-19 / COVID-19 Drug Treatment Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-00243-4

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Heparin / Antibodies, Monoclonal, Humanized / COVID-19 / COVID-19 Drug Treatment Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-00243-4