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Social determinants contribute to disparities in clinical outcome from COVID-19: Data from a multi-ethnic cohort of GU cancer patients
Journal of Urology ; 206(SUPPL 3):e45, 2021.
Article in English | EMBASE | ID: covidwho-1483585
ABSTRACT
INTRODUCTION AND

OBJECTIVE:

The COVID-19 pandemic exploits existing inequalities in the social determinants of health (SDOH) that influence disease burden and access to healthcare. The role of health behaviors and socio-economic status in genitourinary (GU) malignancy, has also been highlighted. Our aim was to evaluate predictors of patient level and neighborhood level factors contributing to disparities in COVID-19 outcomes in GU cancer patients.

METHODS:

Demographic information and co-morbidities for patients screened for COVID-19 across the Mount Sinai Health System (MSHS) up to June 10th, 2020 were included. Descriptive analyses and ensemble feature selection were performed to describe the relationships between these predictors and the outcomes of positive SARS-CoV-2 RT-PCR test, COVID-19 related hospitalization, intubation and death.

RESULTS:

Out of 47,379 tested individuals, 1,094 had a history of GU cancer diagnosis, of these 192 tested positive for SARS-CoV-2. Ensemble feature selection identified social determinants including zipcode, race/ethnicity, age, smoking status and English as preferred first language - as being the majority of significant predictors for each of this study's four COVID-19 related

outcomes:

a positive test, hospitalization, intubation and death.

CONCLUSIONS:

Patient and neighborhood level SDOH including zip code/NYC borough, age, race/ethnicity, smoking status, and English as preferred language are amongst the most significant predictors of these clinically relevant outcomes for COVID-19 patients with a GU cancer. Our results highlight the importance of these SDOH and the need to integrate SDOH in patient EMR with the goal to identify at risk groups. This study's results have implications for COVID-19 research priorities, public health goals, and policy implementations.

Full text: Available Collection: Databases of international organizations Database: EMBASE Type of study: Cohort study / Observational study / Prognostic study Language: English Journal: Journal of Urology Year: 2021 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: EMBASE Type of study: Cohort study / Observational study / Prognostic study Language: English Journal: Journal of Urology Year: 2021 Document Type: Article