Chronic obstructive pulmonary disease and COVID-19: interrelationships.
Curr Opin Pulm Med
; 28(2): 76-83, 2022 03 01.
Article
in English
| MEDLINE | ID: covidwho-1483670
ABSTRACT
PURPOSE OF REVIEW Chronic obstructive pulmonary disease (COPD) and COVID-19 have many potentially negative interrelationships, which may influence the course of infection and clinical outcomes. The aim of this review is to provide clinicians with an up-to-date perspective of the complex interactions between COPD and COVID-19. RECENT FINDINGS:
We consider mechanisms that could increase SARS-CoV-2 infection susceptibility in COPD, including increased ACE2 expression, reduced antiviral defence and dysfunctional immunity. We review evidence that COPD is associated with worse clinical outcomes from COVID-19 in analyses that have adjusted for confounding factors, and describe the mechanisms responsible. We discuss the use of inhaled corticosteroids in the context of susceptibility to COVID-19, and consider the impact of COVID-19 on the usual care of COPD patients.SUMMARY:
The current review highlights the evidence that COPD patients have worse outcomes from COVID-19, and the multiple mechanisms responsible.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pulmonary Disease, Chronic Obstructive
/
COVID-19
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Curr Opin Pulm Med
Year:
2022
Document Type:
Article
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