Mechanisms of Lung Injury Induced by SARS-CoV-2 Infection.
Physiology (Bethesda)
; 37(2): 88-100, 2022 03 01.
Article
in English
| MEDLINE | ID: covidwho-1484087
ABSTRACT
The lung is the major target organ of SARS-CoV-2 infection, which causes COVID-19. Here, we outline the multistep mechanisms of lung epithelial and endothelial injury induced by SARS-CoV-2 direct viral infection, chemokine/cytokine-mediated damage, and immune cell-mediated lung injury. Finally, we discuss the recent progress in terms of antiviral therapeutics as well as the development of anti-inflammatory or immunomodulatory therapeutic approaches. This review also provides a systematic overview of the models for studying SARS-CoV-2 infection and discusses how an understanding of mechanisms of lung injury will help identify potential targets for future drug development to mitigate lung injury.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Lung Injury
/
COVID-19
Type of study:
Reviews
/
Systematic review/Meta Analysis
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Physiology (Bethesda)
Journal subject:
Physiology
Year:
2022
Document Type:
Article
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