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Changes Over Time in COVID-19 Severity and Mortality in Patients Undergoing Cancer Treatment in the United States: Initial Report From the ASCO Registry.
Mileham, Kathryn F; Bruinooge, Suanna S; Aggarwal, Charu; Patrick, Alicia L; Davis, Christiana; Mesenhowski, Daniel J; Spira, Alexander; Clayton, Eric J; Waterhouse, David; Moore, Susan; Jazieh, Abdul-Rahman; Chen, Ronald C; Kaltenbaugh, Melinda; Williams, Jen Hanley; Gralow, Julie R; Schilsky, Richard L; Garrett-Mayer, Elizabeth.
  • Mileham KF; Atrium Health-Levine Cancer Institute, Charlotte, NC.
  • Bruinooge SS; American Society of Clinical Oncology, Alexandria, VA.
  • Aggarwal C; University of Pennsylvania School of Medicine, Abramson Cancer Center, Philadelphia, PA.
  • Patrick AL; Atrium Health-Levine Cancer Institute, Charlotte, NC.
  • Davis C; University of Pennsylvania School of Medicine, Abramson Cancer Center, Philadelphia, PA.
  • Mesenhowski DJ; Virginia Cancer Specialists, US Oncology Research, Fairfax, VA.
  • Spira A; Virginia Cancer Specialists, US Oncology Research, Johns Hopkins Oncology, Fairfax, VA.
  • Clayton EJ; OHC, Cincinnati OH/an Affiliate of US Oncology, Cincinnati, OH.
  • Waterhouse D; OHC, Cincinnati OH/an Affiliate of US Oncology, Cincinnati, OH.
  • Moore S; Virginia Cancer Institute, Richmond, VA.
  • Jazieh AR; Cincinnati Cancer Advisors, Cincinnati, OH.
  • Chen RC; University of Kansas Cancer Center, Kansas City, KS.
  • Kaltenbaugh M; American Society of Clinical Oncology, Alexandria, VA.
  • Williams JH; American Society of Clinical Oncology, Alexandria, VA.
  • Gralow JR; American Society of Clinical Oncology, Alexandria, VA.
  • Schilsky RL; American Society of Clinical Oncology, Alexandria, VA.
  • Garrett-Mayer E; American Society of Clinical Oncology, Alexandria, VA.
JCO Oncol Pract ; 18(4): e426-e441, 2022 Apr.
Article in English | MEDLINE | ID: covidwho-1484816
ABSTRACT

PURPOSE:

People with cancer are at increased risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. ASCO's COVID-19 registry promotes systematic data collection across US oncology practices.

METHODS:

Participating practices enter data on patients with SARS-CoV-2 infection in cancer treatment. In this analysis, we focus on all patients with hematologic or regional or metastatic solid tumor malignancies. Primary outcomes are 30- and 90-day mortality rates and change over time.

RESULTS:

Thirty-eight practices provided data for 453 patients from April to October 2020. Sixty-two percent had regional or metastatic solid tumors. Median age was 64 years. Forty-three percent were current or previous cigarette users. Patients with B-cell malignancies age 61-70 years had twice mortality risk (hazard ratio = 2.1 [95% CI, 1.3 to 3.3]) and those age > 70 years had 4.5 times mortality risk (95% CI, 1.8 to 11.1) compared with patients age ≤ 60 years. Association between survival and age was not significant in patients with metastatic solid tumors (P = .12). Tobacco users had 30-day mortality estimate of 21% compared with 11% for never users (log-rank P = .005). Patients diagnosed with SARS-CoV-2 before June 2020 had 30-day mortality rate of 20% (95% CI, 14% to 25%) compared with 13% (8% to 18%) for those diagnosed in or after June 2020 (P = .08). The 90-day mortality rate for pre-June patients was 28% (21% to 34%) compared with 21% (13% to 28%; P = .20).

CONCLUSION:

Older patients with B-cell malignancies were at increased risk for death (unlike older patients with metastatic solid tumors), as were all patients with cancer who smoke tobacco. Diagnosis of SARS-CoV-2 later in 2020 was associated with more favorable 30- and 90-day mortality, likely related to more asymptomatic cases and improved clinical management.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Neoplasms Limits: Aged / Humans / Middle aged Country/Region as subject: North America Language: English Journal: JCO Oncol Pract Year: 2022 Document Type: Article Affiliation country: OP.21.00394

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Neoplasms Limits: Aged / Humans / Middle aged Country/Region as subject: North America Language: English Journal: JCO Oncol Pract Year: 2022 Document Type: Article Affiliation country: OP.21.00394