COVID-19 Case Fatality and Alzheimer's Disease.

Zhang, Qiang; Schultz, Jordan L; Aldridge, Georgina M; Simmering, Jacob E; Kim, Youngcho; Ogilvie, Amy C; Narayanan, Nandakumar S

Zhang, Qiang; Schultz, Jordan L; Aldridge, Georgina M; Simmering, Jacob E; Kim, Youngcho; Ogilvie, Amy C; Narayanan, Nandakumar S.

Zhang Q; Department of Neurology, University of Iowa, Iowa City, IA, USA.
Schultz JL; Department of Neurology, University of Iowa, Iowa City, IA, USA.
Aldridge GM; Department of Psychiatry, University of Iowa, Iowa City, IA, USA.
Simmering JE; Department of Neurology, University of Iowa, Iowa City, IA, USA.
Kim Y; Department of Internal Medicine, University of Iowa, Iowa City, IA, USA.
Ogilvie AC; Department of Neurology, University of Iowa, Iowa City, IA, USA.
Narayanan NS; Department of Psychiatry, University of Iowa, Iowa City, IA, USA.

J Alzheimers Dis ; 84(4): 1447-1452, 2021.

Article in English | MEDLINE | ID: covidwho-1485013

ABSTRACT

ABSTRACT

Previous studies have identified dementia as a risk factor for death from coronavirus disease 2019 (COVID-19). However, it is unclear whether Alzheimer's disease (AD) is an independent risk factor for COVID-19 case fatality rate. In a retrospective cohort study, we identified 387,841 COVID-19 patients through TriNetX. After adjusting for demographics and comorbidities, we found that AD patients had higher odds of dying from COVID-19 compared to patients without AD (Odds Ratio 1.20, 95%confidence interval 1.09-1.32, pâ<â0.001). Interestingly, we did not observe increased mortality from COVID-19 among patients with vascular dementia. These data are relevant to the evolving COVID-19 pandemic.

Subject(s)

Alzheimer Disease; COVID-19; Alzheimer Disease/complications; Alzheimer Disease/mortality; COVID-19/complications; COVID-19/mortality; Dementia, Vascular/complications; Humans; Retrospective Studies; Risk Factors

Keywords

Alzheimer's disease; Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2); case fatality; dementia with Lewy bodies; frontotemporal dementia; vascular dementia

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Alzheimer Disease / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: J Alzheimers Dis Journal subject: Geriatrics / Neurology Year: 2021 Document Type: Article Affiliation country: JAD-215161

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