Your browser doesn't support javascript.
COVID-19 Is a Multi-Organ Aggressor: Epigenetic and Clinical Marks.
Kgatle, Mankgopo Magdeline; Lawal, Ismaheel Opeyemi; Mashabela, Gabriel; Boshomane, Tebatso Moshoeu Gillian; Koatale, Palesa Caroline; Mahasha, Phetole Walter; Ndlovu, Honest; Vorster, Mariza; Rodrigues, Hosana Gomes; Zeevaart, Jan Rijn; Gordon, Siamon; Moura-Alves, Pedro; Sathekge, Mike Machaba.
  • Kgatle MM; Nuclear Medicine Research Infrastructure (NuMeRI), Steve Biko Academic Hospital, Pretoria, South Africa.
  • Lawal IO; Department of Nuclear Medicine, University of Pretoria & Steve Biko Academic Hospital, Pretoria, South Africa.
  • Mashabela G; Nuclear Medicine Research Infrastructure (NuMeRI), Steve Biko Academic Hospital, Pretoria, South Africa.
  • Boshomane TMG; Department of Nuclear Medicine, University of Pretoria & Steve Biko Academic Hospital, Pretoria, South Africa.
  • Koatale PC; Department of Nuclear Medicine, Steve Biko Academic Hospital, Pretoria, South Africa.
  • Mahasha PW; SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, DSI/NRF Centre of Excellence for Biomedical TB Research, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
  • Ndlovu H; Nuclear Medicine Research Infrastructure (NuMeRI), Steve Biko Academic Hospital, Pretoria, South Africa.
  • Vorster M; Department of Nuclear Medicine, University of Pretoria & Steve Biko Academic Hospital, Pretoria, South Africa.
  • Rodrigues HG; Department of Nuclear Medicine, Steve Biko Academic Hospital, Pretoria, South Africa.
  • Zeevaart JR; Nuclear and Oncology Division, AXIM Medical (Pty), Midrand.
  • Gordon S; Nuclear Medicine Research Infrastructure (NuMeRI), Steve Biko Academic Hospital, Pretoria, South Africa.
  • Moura-Alves P; Department of Nuclear Medicine, University of Pretoria & Steve Biko Academic Hospital, Pretoria, South Africa.
  • Sathekge MM; Precision Medicine and SAMRC Genomic Centre, Grants, Innovation, and Product Development (GIPD) Unit, South African Medical Research Council, Pretoria, South Africa.
Front Immunol ; 12: 752380, 2021.
Article in English | MEDLINE | ID: covidwho-1485056
ABSTRACT
The progression of coronavirus disease 2019 (COVID-19), resulting from a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may be influenced by both genetic and environmental factors. Several viruses hijack the host genome machinery for their own advantage and survival, and similar phenomena might occur upon SARS-CoV-2 infection. Severe cases of COVID-19 may be driven by metabolic and epigenetic driven mechanisms, including DNA methylation and histone/chromatin alterations. These epigenetic phenomena may respond to enhanced viral replication and mediate persistent long-term infection and clinical phenotypes associated with severe COVID-19 cases and fatalities. Understanding the epigenetic events involved, and their clinical significance, may provide novel insights valuable for the therapeutic control and management of the COVID-19 pandemic. This review highlights different epigenetic marks potentially associated with COVID-19 development, clinical manifestation, and progression.
Subject(s)
Keywords
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: DNA Methylation / Epigenesis, Genetic / SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.752380

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: DNA Methylation / Epigenesis, Genetic / SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.752380