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Research Progress in Anti-Inflammatory Bioactive Substances Derived from Marine Microorganisms, Sponges, Algae, and Corals.
Li, Chao-Qun; Ma, Qin-Yuan; Gao, Xiu-Zhen; Wang, Xuan; Zhang, Bei-Li.
  • Li CQ; School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255000, China.
  • Ma QY; School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255000, China.
  • Gao XZ; School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255000, China.
  • Wang X; Key Laboratory of Mariculture (Ministry of Education), Fisheries College, Ocean University of China, Qingdao 266003, China.
  • Zhang BL; Key Laboratory of Aquaculture Nutrition and Feed, Ministry of Agriculture, Ocean University of China, Qingdao 266003, China.
Mar Drugs ; 19(10)2021 Oct 14.
Article in English | MEDLINE | ID: covidwho-1485164
ABSTRACT
Inflammation is the body's defense reaction in response to stimulations and is the basis of various physiological and pathological processes. However, chronic inflammation is undesirable and closely related to the occurrence and development of diseases. The ocean gives birth to unique and diverse bioactive substances, which have gained special attention and been a focus for anti-inflammatory drug development. So far, numerous promising bioactive substances have been obtained from various marine organisms such as marine bacteria and fungi, sponges, algae, and coral. This review covers 71 bioactive substances described during 2015-2020, including the structures (65 of which), species sources, evaluation models and anti-inflammatory activities of these substances. This review aims to provide some reference for the research progress of marine-organism-derived anti-inflammatory metabolites and give more research impetus for their conversion to novel anti-inflammatory drugs.
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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Language: English Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Language: English Year: 2021
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