Cytogenetic Biomonitoring in Buccal Mucosa Cells of COVID-19 Patients: Preliminary Findings.
In Vivo
; 35(6): 3495-3499, 2021.
Article
in English
| MEDLINE | ID: covidwho-1485631
ABSTRACT
BACKGROUND/AIM:
COVID-19 may lead to progressive respiratory failure as a consequence of alveolar damage, resulting in death. The aim of this study was to evaluate cytogenetic damage in oral cells of COVID-19 patients by micronucleus assay. PATIENTS ANDMETHODS:
A total of 11 COVID-19 patients aged 40.7±9.3 years (5 men and 6 women) were included in this study. For the control group, a total of 15 participants not infected with SARS-CoV-2 virus were included. The mean age was 41.6±6.2 years (5 men and 10 women).RESULTS:
The results showed statistically significant differences (p<0.05) in micronucleated buccal mucosa cells of COVID-19 patients. In addittion, a statistically significant increase in karyolysis and karrhyorexis (p<0.05) was observed in COVID-19 patients compared to control.CONCLUSION:
SARS-CoV-2 virus can induce mutagenesis and cytotoxicity in oral cells.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
/
Mouth Mucosa
Type of study:
Experimental Studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
In Vivo
Journal subject:
Neoplasms
Year:
2021
Document Type:
Article
Affiliation country:
Invivo.12651
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