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A Look Inside: Oral Sampling for Detection of Non-oral Infectious Diseases.
Valinetz, Ethan D; Cangelosi, Gerard A.
  • Valinetz ED; Department of Medicine, University of Washington, Seattle, Washington, USA.
  • Cangelosi GA; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA.
J Clin Microbiol ; 59(10): e0236020, 2021 09 20.
Article in English | MEDLINE | ID: covidwho-1486498
ABSTRACT
Efforts to control transmissible infectious diseases rely on the ability to screen large populations, ideally in community settings. These efforts can be limited by the requirement for invasive or logistically difficult collection of patient samples, such as blood, urine, stool, sputum, and nasopharyngeal swabs. Oral sampling is an appealing, noninvasive alternative that could greatly facilitate high-throughput sampling in community settings. Oral sampling has been described for the detection of dozens of human pathogens, including pathogens whose primary sites of infection are outside of the oral cavity, such as the respiratory pathogens Mycobacterium tuberculosis and SARS-CoV-2. Oral sampling can demonstrate active infections as well as resolving or previous infections, the latter through the detection of antibodies. Its potential applications are diverse, including improved diagnosis in special populations (e.g., children), population surveillance, and infectious disease screening. In this minireview, we address the use of oral samples for the detection of diseases that primarily manifest outside the oral cavity. Focusing on well-supported examples, we describe applications for such methods and highlight their potential advantages and limitations in medicine, public health, and research.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Communicable Diseases / COVID-19 Type of study: Diagnostic study Limits: Child / Humans Language: English Journal: J Clin Microbiol Year: 2021 Document Type: Article Affiliation country: Jcm.02360-20

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Communicable Diseases / COVID-19 Type of study: Diagnostic study Limits: Child / Humans Language: English Journal: J Clin Microbiol Year: 2021 Document Type: Article Affiliation country: Jcm.02360-20