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Platelet-derived sCD40L: specific inflammatory marker for early-stage severe acute respiratory syndrome coronavirus 2 infection.
Hamzeh-Cognasse, Hind; Mansour, Alexandre; Reizine, Florian; Mismetti, Patrick; Gouin-Thibault, Isabelle; Cognasse, Fabrice.
  • Hamzeh-Cognasse H; INSERM, U1059, SAINBIOSE, Université de Lyon, Université Jean-Monnet, F-42023, Saint-Etienne, France.
  • Mansour A; Department of Anesthesiology Critical Care Medicine and Perioperative Medicine, CHU de Rennes, F-35000, Rennes, France.
  • Reizine F; INSERM, CIC 1414, Université de Rennes, CHU de Rennes, F-35000, Rennes, France.
  • Mismetti P; Intensive Care Unit, CHU de Rennes, F-35000, Rennes, France.
  • Gouin-Thibault I; INSERM, U1059, SAINBIOSE, Université de Lyon, Université Jean-Monnet, F-42023, Saint-Etienne, France.
  • Cognasse F; Department of Vascular Medicine and Therapeutics, INNOVTE, CHU de St-Etienne, F-42055, Saint-Etienne, France.
Virol J ; 18(1): 211, 2021 10 29.
Article in English | MEDLINE | ID: covidwho-1622247
ABSTRACT

BACKGROUND:

The SARS-CoV-2 virus is the causing agent of the Coronavirus disease 2019 (COVID-19) characterized by a huge pro-inflammatory response and coagulation disorders that may lead to for its severe forms, in organ failure or even death. As major players of thrombo-inflammation, platelets release large amounts of immunomodulatory molecules and regulate leukocyte and endothelial activity, which are both altered in COVID-19. Altogether, this makes platelets a very likely actor of the thrombo-inflammatory complications of COVID-19. Thus, we propose to identify a platelet inflammatory signature of severe COVID-19 specifically modulated throughout the course of the disease.

METHODS:

Luminex technology and enzyme-linked immunosorbent assay were used to assess plasma levels of platelet inflammatory markers in patients with severe acute respiratory syndrome coronavirus 2 infection on admission and for 14 days afterwards.

RESULTS:

In accordance with the observations of other teams, we evidence that the plasma levels of the platelet soluble (s)CD40L is significantly elevated in the early stages of the disease. Interestingly we observe that the plasma level of sCD40L decreases overtime while that of sCD62P increases significantly.

CONCLUSIONS:

Our data suggest that there is a platelet signature of inflammatory response to SARS-COv-2 infection which varies overtime and could serve as monitoring biomarkers of patient inflammatory state. CLINICAL TRIAL REGISTRATION NUMBER 2020-A01100-39; title Human Ab Response & immunoMONItoring of COVID-19 Patients, registration date 05/25/2020; URL of the registry https//clinicaltrials.gov/ct2/history/NCT04373200?V_5=View .
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Platelets / Biomarkers / COVID-19 / Inflammation Type of study: Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Virol J Journal subject: Virology Year: 2021 Document Type: Article Affiliation country: S12985-021-01680-3

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Platelets / Biomarkers / COVID-19 / Inflammation Type of study: Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Virol J Journal subject: Virology Year: 2021 Document Type: Article Affiliation country: S12985-021-01680-3