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Combination of baloxavir and oseltamivir for treatment of severe influenza infection in hematopoietic cell transplant recipients: a novel treatment strategy for a high-risk population.
Angelidakis, Georgios; Khawaja, Fareed; Mulanovich, Victor E; Dailey-Garnes, Natalie; Ariza-Heredia, Ella; Chemaly, Roy F.
  • Angelidakis G; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Khawaja F; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Mulanovich VE; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Dailey-Garnes N; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Ariza-Heredia E; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Chemaly RF; Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: rfchemaly@mdanderson.org.
Microbes Infect ; 24(3): 104895, 2022.
Article in English | MEDLINE | ID: covidwho-1487208
ABSTRACT
Baloxavir, a cap-dependent endonuclease inhibitor, was recently approved for treatment of severe influenza infections. Combining baloxavir with oseltamivir has been proposed to increase the response rate. We report 2 hematopoietic cell transplant recipients with severe influenza infections who were treated with this combination and discuss possible reasons for their different responses.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hematopoietic Stem Cell Transplantation / Influenza, Human Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Microbes Infect Journal subject: Allergy and Immunology / Microbiology Year: 2022 Document Type: Article Affiliation country: J.micinf.2021.104895

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hematopoietic Stem Cell Transplantation / Influenza, Human Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Microbes Infect Journal subject: Allergy and Immunology / Microbiology Year: 2022 Document Type: Article Affiliation country: J.micinf.2021.104895