Your browser doesn't support javascript.
Humoral response to SARS-CoV-2 and seasonal coronaviruses in COVID-19 patients.
Adams, Ortwin; Andrée, Marcel; Rabl, Denise; Ostermann, Philipp N; Schaal, Heiner; Lehnert, Erik; Ackerstaff, Stefanie; Müller, Lisa; Fischer, Johannes C.
  • Adams O; Institute for Virology, Medical Faculty, Heinrich-Heine-University of Duesseldorf, Düsseldorf, Germany.
  • Andrée M; Institute for Virology, Medical Faculty, Heinrich-Heine-University of Duesseldorf, Düsseldorf, Germany.
  • Rabl D; Institute for Virology, Medical Faculty, Heinrich-Heine-University of Duesseldorf, Düsseldorf, Germany.
  • Ostermann PN; Institute for Virology, Medical Faculty, Heinrich-Heine-University of Duesseldorf, Düsseldorf, Germany.
  • Schaal H; Institute for Virology, Medical Faculty, Heinrich-Heine-University of Duesseldorf, Düsseldorf, Germany.
  • Lehnert E; Institute for Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich-Heine-University of Duesseldorf, Düsseldorf, Germany.
  • Ackerstaff S; Institute for Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich-Heine-University of Duesseldorf, Düsseldorf, Germany.
  • Müller L; Institute for Virology, Medical Faculty, Heinrich-Heine-University of Duesseldorf, Düsseldorf, Germany.
  • Fischer JC; Institute for Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich-Heine-University of Duesseldorf, Düsseldorf, Germany.
J Med Virol ; 94(3): 1096-1103, 2022 03.
Article in English | MEDLINE | ID: covidwho-1718376
ABSTRACT
We used enzyme-linked immunoassay methods to measure the prevalence and the levels of antibody responses to the nucleocapsid (N) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and four seasonal human coronaviruses (HCoV-OC43, HCoV-HKU1, HCoV 229E, and HCoV-NL63) in a cohort of 115 convalescent plasma donors infected with SARS-CoV-2 (1-61 days after symptom onset) compared to antibody levels in 114 individuals with no evidence of a recent infection with SARS-CoV-2. In the humoral response to the four seasonal coronaviruses, only HCoV-HKU1- and HCoV-229E-assays showed slightly elevated antibody levels in the COVID group compared to the control group. While in the COVID-group the levels of SARS-CoV-2 antibodies correlated significantly with disease severity, no association was found in the levels of antibodies against the seasonal coronaviruses. The most striking result in both groups was that the levels of antibodies against all tested coronaviruses, including the new SARS-CoV-2 showed a highly significant correlation with each other. There seems to be an individual predisposition to a weaker or stronger humoral immune response against all known seasonal human coronaviruses including the new SARS-CoV-2, which could lead to a definition of low and high responders against human coronaviruses with potential impact on the assessment of postinfection antibody levels and protection.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus 229E, Human / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: J Med Virol Year: 2022 Document Type: Article Affiliation country: Jmv.27427

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus 229E, Human / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: J Med Virol Year: 2022 Document Type: Article Affiliation country: Jmv.27427