Your browser doesn't support javascript.
Uneven metabolic and lipidomic profiles in recovered COVID-19 patients as investigated by plasma NMR metabolomics.
Bizkarguenaga, Maider; Bruzzone, Chiara; Gil-Redondo, Rubén; SanJuan, Itxaso; Martin-Ruiz, Itziar; Barriales, Diego; Palacios, Ainhoa; Pasco, Samuel T; González-Valle, Beatriz; Laín, Ana; Herrera, Lara; Azkarate, Aida; Vesga, Miguel Angel; Eguizabal, Cristina; Anguita, Juan; Embade, Nieves; Mato, José M; Millet, Oscar.
  • Bizkarguenaga M; Precision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance, Derio, Spain.
  • Bruzzone C; Precision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance, Derio, Spain.
  • Gil-Redondo R; Precision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance, Derio, Spain.
  • SanJuan I; Precision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance, Derio, Spain.
  • Martin-Ruiz I; Inflammation and Macrophage Plasticity Laboratory, CIC bioGUNE, Basque Research and Technology Alliance, Derio, Spain.
  • Barriales D; Inflammation and Macrophage Plasticity Laboratory, CIC bioGUNE, Basque Research and Technology Alliance, Derio, Spain.
  • Palacios A; Inflammation and Macrophage Plasticity Laboratory, CIC bioGUNE, Basque Research and Technology Alliance, Derio, Spain.
  • Pasco ST; Inflammation and Macrophage Plasticity Laboratory, CIC bioGUNE, Basque Research and Technology Alliance, Derio, Spain.
  • González-Valle B; Precision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance, Derio, Spain.
  • Laín A; Precision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance, Derio, Spain.
  • Herrera L; Research Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain.
  • Azkarate A; Cell Therapy, Stem Cells and Tissues Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.
  • Vesga MA; Research Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain.
  • Eguizabal C; Cell Therapy, Stem Cells and Tissues Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.
  • Anguita J; Research Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain.
  • Embade N; Cell Therapy, Stem Cells and Tissues Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.
  • Mato JM; Research Unit, Basque Center for Blood Transfusion and Human Tissues, Osakidetza, Galdakao, Spain.
  • Millet O; Cell Therapy, Stem Cells and Tissues Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.
NMR Biomed ; 35(2): e4637, 2022 02.
Article in English | MEDLINE | ID: covidwho-1487509
ABSTRACT
COVID-19 is a systemic infectious disease that may affect many organs, accompanied by a measurable metabolic dysregulation. The disease is also associated with significant mortality, particularly among the elderly, patients with comorbidities, and solid organ transplant recipients. Yet, the largest segment of the patient population is asymptomatic, and most other patients develop mild to moderate symptoms after SARS-CoV-2 infection. Here, we have used NMR metabolomics to characterize plasma samples from a cohort of the abovementioned group of COVID-19 patients (n = 69), between 3 and 10 months after diagnosis, and compared them with a set of reference samples from individuals never infected by the virus (n = 71). Our results indicate that half of the patient population show abnormal metabolism including porphyrin levels and altered lipoprotein profiles six months after the infection, while the other half show little molecular record of the disease. Remarkably, most of these patients are asymptomatic or mild COVID-19 patients, and we hypothesize that this is due to a metabolic reflection of the immune response stress.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Magnetic Resonance Spectroscopy / Metabolomics / Lipidomics / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Humans Language: English Journal: NMR Biomed Journal subject: Diagnostic Imaging / Nuclear Medicine Year: 2022 Document Type: Article Affiliation country: Nbm.4637

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Magnetic Resonance Spectroscopy / Metabolomics / Lipidomics / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Humans Language: English Journal: NMR Biomed Journal subject: Diagnostic Imaging / Nuclear Medicine Year: 2022 Document Type: Article Affiliation country: Nbm.4637