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Statin withdrawal and treating COVID-19 patients.
Fedson, David S.
  • Fedson DS; Sergy Haut, France.
Pharmacol Res Perspect ; 9(6): e00861, 2021 12.
Article in English | MEDLINE | ID: covidwho-1487514
ABSTRACT
Most but not all observational studies of statin treatment of COVID-19 patients suggest that treatment improves outcomes. However, almost all of these studies fail to consider that withdrawing statins after hospital admission may have detrimental effects, a finding which cardiovascular investigators have known for 15-20 years. Continuing or starting statin treatment after hospital admission consistently improves cardiovascular outcomes. Similarly, inpatient statin treatment of COVID-19 improves survival. For this reason, observational studies of the effectiveness of outpatient-documented statin treatment of COVID-19 patients must consider the negative consequences of statin withdrawal after hospital admission.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hydroxymethylglutaryl-CoA Reductase Inhibitors / COVID-19 Drug Treatment Type of study: Observational study / Prognostic study / Randomized controlled trials / Reviews Limits: Humans Language: English Journal: Pharmacol Res Perspect Year: 2021 Document Type: Article Affiliation country: Prp2.861

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hydroxymethylglutaryl-CoA Reductase Inhibitors / COVID-19 Drug Treatment Type of study: Observational study / Prognostic study / Randomized controlled trials / Reviews Limits: Humans Language: English Journal: Pharmacol Res Perspect Year: 2021 Document Type: Article Affiliation country: Prp2.861