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Possible Reactivation of SARS-CoV-2 in a Patient with Acute Myeloid Leukemia Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: a Case Report.
Dalla Via, Vera; von Rotz, Matthias; Bättig, Veronika; Leuzinger, Karoline; Hirsch, Hans H; Passweg, Jakob; Stüssi, Georg; Medinger, Michael.
  • Dalla Via V; Division of Hematology, Department of Medicine, University Hospital Basel and University of Basel, Petersgraben 4, CH-4031 Basel, Switzerland.
  • von Rotz M; Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel and University of Basel, Basel, Switzerland.
  • Bättig V; Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel and University of Basel, Basel, Switzerland.
  • Leuzinger K; Clinical Virology, Laboratory Medicine, University Hospital Basel, Basel, Switzerland.
  • Hirsch HH; Transplantation and Clinical Virology, Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Passweg J; Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel and University of Basel, Basel, Switzerland.
  • Stüssi G; Clinical Virology, Laboratory Medicine, University Hospital Basel, Basel, Switzerland.
  • Medinger M; Transplantation and Clinical Virology, Department of Biomedicine, University of Basel, Basel, Switzerland.
SN Compr Clin Med ; 3(10): 2011-2015, 2021.
Article in English | MEDLINE | ID: covidwho-1487551
ABSTRACT
Reactivation or reinfection cases of SARS-CoV-2 are known but there is scarce evidence about reactivation in immunocompromised patients. Here, we report the case of a 61-year-old male undergoing a conditioning regimen with fludarabine, cyclophosphamide, and 2-Gy total body irradiation in preparation of a haplo-identical allogeneic hematopoietic stem cell transplantation (allo-HSCT) for acute myeloid leukemia (AML). He received the first dose of a COVID-19 vaccine 6 weeks prior allo-HSCT and was hospitalized a month prior because of a COVID-19 bilateral pneumonia. On discharge, he showed two negative SARS-CoV-2 nasopharyngeal PCR swabs as well as a high SARS-CoV-2 antibody titer. On admission for allo-HSCT, he tested negative for SARS-CoV-2 again. Conditioning with fludarabine, cyclophosphamide, and 2-Gy total body irradiation was started and the patient developed lymphopenia. During his hospital stay, he tested positive for SARS-CoV-2 in a PCR test twice but remained asymptomatic. The conditioning regimen was continued as planned. Later during his stay, the patient showed undetectable SARS-CoV-2 load four times. This case documents possible reactivation of SARS-CoV-2 and raises questions about reactivation risks among recipients of stem cell transplants and other immunocompromised patients.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Prognostic study Topics: Vaccines Language: English Journal: SN Compr Clin Med Year: 2021 Document Type: Article Affiliation country: S42399-021-01020-0

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Prognostic study Topics: Vaccines Language: English Journal: SN Compr Clin Med Year: 2021 Document Type: Article Affiliation country: S42399-021-01020-0