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COVID-19 vaccination in patients with breast cancer and gynecological malignancies: A German perspective.
Forster, Marie; Wuerstlein, Rachel; Koenig, Alexander; Amann, Niklas; Beyer, Susanne; Kaltofen, Till; Degenhardt, Tom; Burges, Alexander; Trillsch, Fabian; Mahner, Sven; Harbeck, Nadia; Chelariu-Raicu, Anca.
  • Forster M; Department of Obstetrics and Gynecology, Breast Center, Gynecologic Oncology Center and CCC Munich, LMU University Hospital, Marchioninistraße 15, 81337, Munich, Germany.
  • Wuerstlein R; Department of Obstetrics and Gynecology, Breast Center, Gynecologic Oncology Center and CCC Munich, LMU University Hospital, Marchioninistraße 15, 81337, Munich, Germany.
  • Koenig A; Department of Obstetrics and Gynecology, Breast Center, Gynecologic Oncology Center and CCC Munich, LMU University Hospital, Marchioninistraße 15, 81337, Munich, Germany.
  • Amann N; Department of Obstetrics and Gynecology, Breast Center, Gynecologic Oncology Center and CCC Munich, LMU University Hospital, Marchioninistraße 15, 81337, Munich, Germany.
  • Beyer S; Department of Obstetrics and Gynecology, Breast Center, Gynecologic Oncology Center and CCC Munich, LMU University Hospital, Marchioninistraße 15, 81337, Munich, Germany.
  • Kaltofen T; Department of Obstetrics and Gynecology, Breast Center, Gynecologic Oncology Center and CCC Munich, LMU University Hospital, Marchioninistraße 15, 81337, Munich, Germany.
  • Degenhardt T; Department of Obstetrics and Gynecology, Breast Center, Gynecologic Oncology Center and CCC Munich, LMU University Hospital, Marchioninistraße 15, 81337, Munich, Germany.
  • Burges A; Department of Obstetrics and Gynecology, Breast Center, Gynecologic Oncology Center and CCC Munich, LMU University Hospital, Marchioninistraße 15, 81337, Munich, Germany.
  • Trillsch F; Department of Obstetrics and Gynecology, Breast Center, Gynecologic Oncology Center and CCC Munich, LMU University Hospital, Marchioninistraße 15, 81337, Munich, Germany.
  • Mahner S; Department of Obstetrics and Gynecology, Breast Center, Gynecologic Oncology Center and CCC Munich, LMU University Hospital, Marchioninistraße 15, 81337, Munich, Germany.
  • Harbeck N; Department of Obstetrics and Gynecology, Breast Center, Gynecologic Oncology Center and CCC Munich, LMU University Hospital, Marchioninistraße 15, 81337, Munich, Germany.
  • Chelariu-Raicu A; Department of Obstetrics and Gynecology, Breast Center, Gynecologic Oncology Center and CCC Munich, LMU University Hospital, Marchioninistraße 15, 81337, Munich, Germany. Electronic address: Anca.Chelariu-Raicu@med.uni-muenchen.de.
Breast ; 60: 214-222, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1487619
ABSTRACT

INTRODUCTION:

The side effects of systemic cancer therapy and the lack of clinical data on safety and efficacy of COVID-19 vaccination in cancer patients cause uncertainty among the patients about whether to get vaccinated or not. Here, we evaluated attitude towards and effects of COVID-19 vaccination in patients with breast and gynecological cancer undergoing systemic cancer therapy.

METHODS:

Since March 15th, 2021, cancer patients who received one of the approved COVID-19 vaccines were routinely interviewed about immediate and late side effects. Clinical parameters such as current therapy, time interval between therapy administration and vaccination, and changes in the therapy schedule due to vaccination were documented. The collected data were analyzed de-identified as a part of routine quality assurance.

RESULTS:

By July 27th, 2021, 218 patients (74.3% breast cancer patients) had received one of two COVID-19 vaccine doses, and 112 patients had received both doses 77.5% received Conmirnaty (BioNTech/Pfizer), 16.1% Vaxzevria (Astra Zeneca) and 5.9% COVID-19 Vaccine Moderna. The COVID-19 vaccines had an acceptable safety profile with self-limiting local and systemic adverse events, which rarely lasted >48 h post vaccination. Symptoms occurred predominantly after the second dose of the vaccine and less frequently in older patients >55 years. No vaccine-related serious adverse events were reported, and only limited effects of vaccination on the therapy schedule were observed.

CONCLUSIONS:

Breast and gynecologic cancer patients tolerate the COVID-19 vaccination while undergoing systemic cancer therapy without any additional side effects beyond those reported in the general population.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Breast Neoplasms / COVID-19 / Genital Neoplasms, Female Type of study: Experimental Studies / Prognostic study Topics: Long Covid / Vaccines Limits: Aged / Female / Humans Language: English Journal: Breast Journal subject: Endocrinology / Neoplasms Year: 2021 Document Type: Article Affiliation country: J.breast.2021.10.012

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Breast Neoplasms / COVID-19 / Genital Neoplasms, Female Type of study: Experimental Studies / Prognostic study Topics: Long Covid / Vaccines Limits: Aged / Female / Humans Language: English Journal: Breast Journal subject: Endocrinology / Neoplasms Year: 2021 Document Type: Article Affiliation country: J.breast.2021.10.012