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Advantages and disadvantages of disulfiram coadministered with popular addictive substances.
Kleczkowska, Patrycja; Sulejczak, Dorota; Zaremba, Malgorzata.
  • Kleczkowska P; Department of Pharmacodynamics, Centre for Preclinical Research (CBP), Medical University of Warsaw, 02-097, Warsaw, Poland; Military Institute of Hygiene and Epidemiology, 01-163, Warsaw, Poland. Electronic address: hazufiel@wp.pl.
  • Sulejczak D; Department of Experimental Pharmacology, Mossakowski Medical Research Institute, Polish Academy of Sciences, 02-106, Warsaw, Poland.
  • Zaremba M; Military Institute of Hygiene and Epidemiology, 01-163, Warsaw, Poland; Department of Experimental and Clinical Pharmacology, Centre for Preclinical Research (CBP), Medical University of Warsaw, 02-097, Warsaw, Poland.
Eur J Pharmacol ; 904: 174143, 2021 Aug 05.
Article in English | MEDLINE | ID: covidwho-1487708
Semantic information from SemMedBD (by NLM)
1. disulfiram INHIBITS aldehyde dehydrogenases
Subject
disulfiram
Predicate
INHIBITS
Object
aldehyde dehydrogenases
2. disulfiram CAUSES Symptoms
Subject
disulfiram
Predicate
CAUSES
Object
Symptoms
3. Pharmaceutical Preparations TREATS DRUG ABUSE DECREASE
Subject
Pharmaceutical Preparations
Predicate
TREATS
Object
DRUG ABUSE DECREASE
4. Pharmaceutical Preparations TREATS Alcoholic Intoxicatio
Subject
Pharmaceutical Preparations
Predicate
TREATS
Object
Alcoholic Intoxicatio
5. disulfiram COEXISTS_WITH Pharmaceutical Preparations
Subject
disulfiram
Predicate
COEXISTS_WITH
Object
Pharmaceutical Preparations
6. disulfiram INHIBITS aldehyde dehydrogenases
Subject
disulfiram
Predicate
INHIBITS
Object
aldehyde dehydrogenases
7. disulfiram CAUSES Symptoms
Subject
disulfiram
Predicate
CAUSES
Object
Symptoms
8. Pharmaceutical Preparations TREATS DRUG ABUSE DECREASE
Subject
Pharmaceutical Preparations
Predicate
TREATS
Object
DRUG ABUSE DECREASE
9. Pharmaceutical Preparations TREATS Alcoholic Intoxication, Chronic
Subject
Pharmaceutical Preparations
Predicate
TREATS
Object
Alcoholic Intoxication, Chronic
10. disulfiram COEXISTS_WITH Pharmaceutical Preparations
Subject
disulfiram
Predicate
COEXISTS_WITH
Object
Pharmaceutical Preparations
ABSTRACT
Disulfiram (DSF) is a well-known anti-alcohol agent that inhibits aldehyde dehydrogenase and results in extreme 'hangover' symptoms when consumed with alcohol. This drug, however, has been suggested as useful in other forms of drug addiction due to its beneficial potential in both drug abuse reduction and withdrawal. However, among other drugs used in alcohol dependence, it carries the greatest risk of pharmacological interactions. Concomitant use of DSF and central nervous system stimulants usually leads to harmful, undesirable effects. To date, there is still limited data regarding the detailed safety profile of DSF as a concomitant drug. In this review article, we outline the current state of knowledge about DSF, its broad pharmacological action, as well as therapeutic effects, with a particular emphasis on the molecular understanding of its potential pharmacodynamic interactions with common addictive substances (e.g., alcohol, cocaine, cannabinoids, opioids) supported by relevant examples.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Substance-Related Disorders / Disulfiram / Acetaldehyde Dehydrogenase Inhibitors Limits: Animals / Humans Language: English Journal: Eur J Pharmacol Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Substance-Related Disorders / Disulfiram / Acetaldehyde Dehydrogenase Inhibitors Limits: Animals / Humans Language: English Journal: Eur J Pharmacol Year: 2021 Document Type: Article