Advantages and disadvantages of disulfiram coadministered with popular addictive substances.
Eur J Pharmacol
; 904: 174143, 2021 Aug 05.
Article
in English
| MEDLINE | ID: covidwho-1487708
ABSTRACT
Disulfiram (DSF) is a well-known anti-alcohol agent that inhibits aldehyde dehydrogenase and results in extreme 'hangover' symptoms when consumed with alcohol. This drug, however, has been suggested as useful in other forms of drug addiction due to its beneficial potential in both drug abuse reduction and withdrawal. However, among other drugs used in alcohol dependence, it carries the greatest risk of pharmacological interactions. Concomitant use of DSF and central nervous system stimulants usually leads to harmful, undesirable effects. To date, there is still limited data regarding the detailed safety profile of DSF as a concomitant drug. In this review article, we outline the current state of knowledge about DSF, its broad pharmacological action, as well as therapeutic effects, with a particular emphasis on the molecular understanding of its potential pharmacodynamic interactions with common addictive substances (e.g., alcohol, cocaine, cannabinoids, opioids) supported by relevant examples.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Substance-Related Disorders
/
Disulfiram
/
Acetaldehyde Dehydrogenase Inhibitors
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Eur J Pharmacol
Year:
2021
Document Type:
Article
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