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Post-acute COVID-19 syndrome after reinfection and vaccine breakthrough by the SARS-CoV-2 Gamma variant in Brazil.
Penetra, Stephanie L S; da Silva, Michele F B; Resende, Paola; Pina-Costa, Anielle; Santos, Heloisa F P; Guaraldo, Lusiele; Calvet, Guilherme A; Ogrzewalska, Maria; Arantes, Ighor; Zukeram, Ketiuce; de Araújo, Mia F; Lima, Ana Beatriz Machado; Lopes, Renata Serrano; Lira-Silva, Larissa R; Moraes, Isabella V; Wakimoto, Mayumi D; Fuller, Trevon L; Gabaglia, Claudia Raja; Espíndola, Otávio M; Bonaldo, Myrna C; Daniel-Ribeiro, Cláudio Tadeu; Whitworth, Jimmy; Smith, Chris; Nielsen-Saines, Karin; Pauvolid-Correa, Alex; Siqueira, Marilda M; Brasil, Patricia.
  • Penetra SLS; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
  • da Silva MFB; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
  • Resende P; Laboratory of Respiratory Viruses and Measles National Influenza Centre (GISRS-WHO) - Americas Regional Reference Lab for Measles and Rubella - Reference Laboratory for COVID-19 (WHO), Oswaldo Cruz Institute, (IOC), Fiocruz. Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
  • Pina-Costa A; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil; Serra dos Órgãos Education Foundation, Avenida Alberto Tôrres, 111 - Alto, Teresópolis, RJ, 25964-004, Brazil.
  • Santos HFP; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
  • Guaraldo L; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
  • Calvet GA; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
  • Ogrzewalska M; Laboratory of Respiratory Viruses and Measles National Influenza Centre (GISRS-WHO) - Americas Regional Reference Lab for Measles and Rubella - Reference Laboratory for COVID-19 (WHO), Oswaldo Cruz Institute, (IOC), Fiocruz. Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
  • Arantes I; Laboratory of Respiratory Viruses and Measles National Influenza Centre (GISRS-WHO) - Americas Regional Reference Lab for Measles and Rubella - Reference Laboratory for COVID-19 (WHO), Oswaldo Cruz Institute, (IOC), Fiocruz. Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
  • Zukeram K; Laboratory of Respiratory Viruses and Measles National Influenza Centre (GISRS-WHO) - Americas Regional Reference Lab for Measles and Rubella - Reference Laboratory for COVID-19 (WHO), Oswaldo Cruz Institute, (IOC), Fiocruz. Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
  • de Araújo MF; Laboratory of Respiratory Viruses and Measles National Influenza Centre (GISRS-WHO) - Americas Regional Reference Lab for Measles and Rubella - Reference Laboratory for COVID-19 (WHO), Oswaldo Cruz Institute, (IOC), Fiocruz. Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
  • Lima ABM; Laboratory of Respiratory Viruses and Measles National Influenza Centre (GISRS-WHO) - Americas Regional Reference Lab for Measles and Rubella - Reference Laboratory for COVID-19 (WHO), Oswaldo Cruz Institute, (IOC), Fiocruz. Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
  • Lopes RS; Laboratory of Respiratory Viruses and Measles National Influenza Centre (GISRS-WHO) - Americas Regional Reference Lab for Measles and Rubella - Reference Laboratory for COVID-19 (WHO), Oswaldo Cruz Institute, (IOC), Fiocruz. Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
  • Lira-Silva LR; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
  • Moraes IV; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
  • Wakimoto MD; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
  • Fuller TL; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil; University of California, Los Angeles (UCLA), Box 951752, 10833 Le Conte Avenue 22-442 MDCC, Los Angeles, CA, 90095-1752, USA.
  • Gabaglia CR; Biomedical Research Institute of Southern California (BRISC), 4263 Oceanside Blvd#106-159, Oceanside, CA, 92056, USA.
  • Espíndola OM; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
  • Bonaldo MC; Laboratory of Molecular Biology, Oswaldo Cruz Institute, Fiocruz, Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ 21040-3608, Brazil.
  • Daniel-Ribeiro CT; Department of Immunology, Oswaldo Cruz Institute, Fiocruz, Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
  • Whitworth J; Department of Clinical Research, London School of Hygiene and Tropical Medicine, Keppel St, London, WC1E 7HT, United Kingdom.
  • Smith C; Department of Clinical Research, London School of Hygiene and Tropical Medicine, Keppel St, London, WC1E 7HT, United Kingdom.
  • Nielsen-Saines K; University of California, Los Angeles (UCLA), Box 951752, 10833 Le Conte Avenue 22-442 MDCC, Los Angeles, CA, 90095-1752, USA.
  • Pauvolid-Correa A; Laboratory of Respiratory Viruses and Measles National Influenza Centre (GISRS-WHO) - Americas Regional Reference Lab for Measles and Rubella - Reference Laboratory for COVID-19 (WHO), Oswaldo Cruz Institute, (IOC), Fiocruz. Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil; T
  • Siqueira MM; Laboratory of Respiratory Viruses and Measles National Influenza Centre (GISRS-WHO) - Americas Regional Reference Lab for Measles and Rubella - Reference Laboratory for COVID-19 (WHO), Oswaldo Cruz Institute, (IOC), Fiocruz. Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil.
  • Brasil P; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) Avenida Brasil 4365 - Manguinhos, Rio de Janeiro, RJ, 21040-3608, Brazil. Electronic address: patricia.brasil@ini.fiocruz.br.
Int J Infect Dis ; 114: 58-61, 2022 Jan.
Article in English | MEDLINE | ID: covidwho-1487754
ABSTRACT
We describe a case of prolonged COVID-19 caused by the SARS-CoV-2 Gamma variant in a fully vaccinated healthcare worker, 387 days after an infection caused by lineage B.1.1.33. Infections were confirmed by whole-genome sequencing and corroborated by the detection of neutralizing antibodies in convalescent serum samples. Considering the permanent exposure of this healthcare worker to SARS-CoV-2, the waning immunity after the first infection, the low efficacy of the inactivated vaccine at preventing COVID-19, the immune escape of the Gamma variant (VOC), and the burden of post-COVID syndrome, this individual would have benefited from an additional dose of a heterologous vaccine.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Case report Topics: Long Covid / Vaccines / Variants Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: J.ijid.2021.10.048

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Case report Topics: Long Covid / Vaccines / Variants Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: J.ijid.2021.10.048