Your browser doesn't support javascript.
HDL proteome remodeling associates with COVID-19 severity.
Souza Junior, Douglas Ricardo; Silva, Amanda Ribeiro Martins; Rosa-Fernandes, Livia; Reis, Lorenna Rocha; Alexandria, Gabrielly; Bhosale, Santosh D; Ghilardi, Fabio de Rose; Dalçóquio, Talia Falcão; Bertolin, Adriadne Justi; Nicolau, José Carlos; Marinho, Claudio R F; Wrenger, Carsten; Larsen, Martin R; Siciliano, Rinaldo Focaccia; Di Mascio, Paolo; Palmisano, Giuseppe; Ronsein, Graziella Eliza.
  • Souza Junior DR; Department of Biochemistry, Chemistry Institute, University of São Paulo, São Paulo, Brazil.
  • Silva ARM; Department of Biochemistry, Chemistry Institute, University of São Paulo, São Paulo, Brazil.
  • Rosa-Fernandes L; Department of Parasitology, Institute of Biomedical Science, University of São Paulo, São Paulo, Brazil.
  • Reis LR; Department of Biochemistry, Chemistry Institute, University of São Paulo, São Paulo, Brazil.
  • Alexandria G; Department of Biochemistry, Chemistry Institute, University of São Paulo, São Paulo, Brazil.
  • Bhosale SD; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
  • Ghilardi FR; Institute for Tropical Medicine, University of São Paulo, São Paulo, Brazil.
  • Dalçóquio TF; Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.
  • Bertolin AJ; Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.
  • Nicolau JC; Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.
  • Marinho CRF; Department of Parasitology, Institute of Biomedical Science, University of São Paulo, São Paulo, Brazil.
  • Wrenger C; Department of Parasitology, Institute of Biomedical Science, University of São Paulo, São Paulo, Brazil.
  • Larsen MR; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
  • Siciliano RF; Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil; Division of Infectious and Parasitic Diseases, University of São Paulo Medical School, São Paulo, Brazil.
  • Di Mascio P; Department of Biochemistry, Chemistry Institute, University of São Paulo, São Paulo, Brazil.
  • Palmisano G; Department of Parasitology, Institute of Biomedical Science, University of São Paulo, São Paulo, Brazil. Electronic address: palmisano.gp@usp.br.
  • Ronsein GE; Department of Biochemistry, Chemistry Institute, University of São Paulo, São Paulo, Brazil. Electronic address: ronsein@iq.usp.br.
J Clin Lipidol ; 15(6): 796-804, 2021.
Article in English | MEDLINE | ID: covidwho-1487791
ABSTRACT

BACKGROUND:

Besides the well-accepted role in lipid metabolism, high-density lipoprotein (HDL) also seems to participate in host immune response against infectious diseases.

OBJECTIVE:

We used a quantitative proteomic approach to test the hypothesis that alterations in HDL proteome associate with severity of Coronavirus disease 2019 (COVID-19).

METHODS:

Based on clinical criteria, subjects (n=41) diagnosed with COVID-19 were divided into two groups a group of subjects presenting mild symptoms and a second group displaying severe symptoms and requiring hospitalization. Using a proteomic approach, we quantified the levels of 29 proteins in HDL particles derived from these subjects.

RESULTS:

We showed that the levels of serum amyloid A 1 and 2 (SAA1 and SAA2, respectively), pulmonary surfactant-associated protein B (SFTPB), apolipoprotein F (APOF), and inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) were increased by more than 50% in hospitalized patients, independently of sex, HDL-C or triglycerides when comparing with subjects presenting only mild symptoms. Altered HDL proteins were able to classify COVID-19 subjects according to the severity of the disease (error rate 4.9%). Moreover, apolipoprotein M (APOM) in HDL was inversely associated with odds of death due to COVID-19 complications (odds ratio [OR] per 1-SD increase in APOM was 0.27, with 95% confidence interval [CI] of 0.07 to 0.72, P=0.007).

CONCLUSION:

Our results point to a profound inflammatory remodeling of HDL proteome tracking with severity of COVID-19 infection. They also raise the possibility that HDL particles could play an important role in infectious diseases.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Lipoproteins, HDL Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: J Clin Lipidol Journal subject: Biochemistry / Metabolism Year: 2021 Document Type: Article Affiliation country: J.jacl.2021.10.005

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Lipoproteins, HDL Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: J Clin Lipidol Journal subject: Biochemistry / Metabolism Year: 2021 Document Type: Article Affiliation country: J.jacl.2021.10.005