Impact of Allergic Rhinitis and Asthma on COVID-19 Infection, Hospitalization, and Mortality.
J Allergy Clin Immunol Pract
; 10(1): 124-133, 2022 01.
Article
in English
| MEDLINE | ID: covidwho-1487804
ABSTRACT
BACKGROUND:
It remains unclear if patients with allergic rhinitis (AR) and/or asthma are susceptible to corona virus disease 2019 (COVID-19) infection, severity, and mortality.OBJECTIVE:
To investigate the role of AR and/or asthma in COVID-19 infection, severity, and mortality, and assess whether long-term AR and/or asthma medications affected the outcomes of COVID-19.METHODS:
Demographic and clinical data of 70,557 adult participants completed SARS-CoV-2 testing between March 16 and December 31, 2020, in the UK Biobank were analyzed. The rates of COVID-19 infection, hospitalization, and mortality in relation to pre-existing AR and/or asthma were assessed based on adjusted generalized linear models. We further analyzed the impact of long-term AR and/or asthma medications on the risk of COVID-19 hospitalization and mortality.RESULTS:
Patients with AR of all ages had lower positive rates of SARS-CoV-2 tests (relative risk [RR] 0.75, 95% confidence interval [CI] 0.69-0.81, P < .001), with lower susceptibility in males (RR 0.74, 95% CI 0.65-0.85, P < .001) than females (RR 0.8, 95% CI 0.72-0.9, P < .001). However, similar effects of asthma against COVID-19 hospitalization were only major in participants aged <65 (RR 0.93, 95% CI 0.86-1, P = .044) instead of elderlies. In contrast, patients with asthma tested positively had higher risk of hospitalization (RR 1.42, 95% CI 1.32-1.54, P < .001). Neither AR nor asthma had an impact on COVID-19 mortality. None of conventional medications for AR or asthma, for example, antihistamines, corticosteroids, or ß2 adrenoceptor agonists, showed association with COVID-19 infection or severity.CONCLUSION:
AR (all ages) and asthma (aged <65) act as protective factors against COVID-19 infection, whereas asthma increases risk for COVID-19 hospitalization. None of the long-term medications had a significant association with infection, severity, and mortality of COVID-19 among patients with AR and/or asthma.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Asthma
/
Rhinitis, Allergic
/
COVID-19
Type of study:
Diagnostic study
/
Etiology study
/
Experimental Studies
/
Prognostic study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
J Allergy Clin Immunol Pract
Year:
2022
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS