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A Case Report of Posttransplant Lymphoproliferative Disorder After AstraZeneca Coronavirus Disease 2019 Vaccine in a Heart Transplant Recipient.
Tang, Wen-Ruei; Hsu, Che-Wei; Lee, Chia-Chi; Huang, Wei-Li; Lin, Chia-Ying; Hsu, Ya-Ting; Chang, Chen; Tsai, Meng-Ta; Hu, Yu-Ning; Hsu, Chih-Hsin; Chen, Po-Lin; Chow, Nan-Haw; Roan, Jun-Neng.
  • Tang WR; Division of Thoracic Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • Hsu CW; Department of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • Lee CC; Division of Thoracic Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • Huang WL; Division of Thoracic Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • Lin CY; Department of Medical Imaging, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • Hsu YT; Division of Hematology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • Chang C; Department of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • Tsai MT; Division of Cardiovascular Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • Hu YN; Division of Cardiovascular Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • Hsu CH; Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • Chen PL; Center for Infection Control and Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • Chow NH; Department of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • Roan JN; Division of Cardiovascular Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address: 102h0019@gs.ncku.edu.tw.
Transplant Proc ; 54(6): 1575-1578, 2022.
Article in English | MEDLINE | ID: covidwho-1487992
ABSTRACT
We report a case of a heart transplant recipient who presented with a rapidly growing Epstein-Barr virus (EBV)-positive, diffuse large B-cell lymphoma 7 days after receiving the first dose of the ChAdOx1 nCoV-19 vaccine. Because of the atypical radiologic presentation, the initial tentative diagnosis was a mediastinal abscess. This observation indicates a potential risk of EBV reactivation after coronavirus disease 2019 (COVID-19) vaccination, which might lead to or aggravate the presentation of posttransplant lymphoproliferative disorder in transplantation patients. Transplant surgeons should be aware of the potential immunomodulatory effects of the COVID-19 vaccination.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Heart Transplantation / Epstein-Barr Virus Infections / COVID-19 / ChAdOx1 nCoV-19 / Lymphoproliferative Disorders Type of study: Case report / Diagnostic study / Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Transplant Proc Year: 2022 Document Type: Article Affiliation country: J.transproceed.2021.09.006

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Heart Transplantation / Epstein-Barr Virus Infections / COVID-19 / ChAdOx1 nCoV-19 / Lymphoproliferative Disorders Type of study: Case report / Diagnostic study / Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Transplant Proc Year: 2022 Document Type: Article Affiliation country: J.transproceed.2021.09.006