Recent ultrasound advancements for the manipulation of nanobiomaterials and nanoformulations for drug delivery.
Ultrason Sonochem
; 80: 105805, 2021 Dec.
Article
in English
| MEDLINE | ID: covidwho-1487995
ABSTRACT
Recent advances in ultrasound (US) have shown its great potential in biomedical applications as diagnostic and therapeutic tools. The coupling of US-assisted drug delivery systems with nanobiomaterials possessing tailor-made functions has been shown to remove the limitations of conventional drug delivery systems. The low-frequency US has significantly enhanced the targeted drug delivery effect and efficacy, reducing limitations posed by conventional treatments such as a limited therapeutic window. The acoustic cavitation effect induced by the US-mediated microbubbles (MBs) has been reported to replace drugs in certain acute diseases such as ischemic stroke. This review briefly discusses the US principles, with particular attention to the recent advancements in drug delivery applications. Furthermore, US-assisted drug delivery coupled with nanobiomaterials to treat different diseases (cancer, neurodegenerative disease, diabetes, thrombosis, and COVID-19) are discussed in detail. Finally, this review covers the future perspectives and challenges on the applications of US-mediated nanobiomaterials.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Biocompatible Materials
/
Ultrasonography
/
Drug Delivery Systems
/
Microbubbles
/
Nanostructures
Limits:
Humans
Language:
English
Journal:
Ultrason Sonochem
Journal subject:
Diagnostic Imaging
Year:
2021
Document Type:
Article
Affiliation country:
J.ultsonch.2021.105805
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