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Zn2+-Dependent peptide nucleic acid-based artificial ribonucleases with unprecedented efficiency and specificity.
Luige, Olivia; Bose, Partha Pratim; Stulz, Rouven; Steunenberg, Peter; Brun, Omar; Andersson, Shalini; Murtola, Merita; Strömberg, Roger.
  • Luige O; Department of Biosciences and Nutrition, Karolinska Institutet, Neo, 141 83 Huddinge, Sweden. Roger.Stromberg@ki.se.
  • Bose PP; Department of Biosciences and Nutrition, Karolinska Institutet, Neo, 141 83 Huddinge, Sweden. Roger.Stromberg@ki.se.
  • Stulz R; Department of Biosciences and Nutrition, Karolinska Institutet, Neo, 141 83 Huddinge, Sweden. Roger.Stromberg@ki.se.
  • Steunenberg P; Oligonucleotide Discovery, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Brun O; DMPK, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Andersson S; Department of Biosciences and Nutrition, Karolinska Institutet, Neo, 141 83 Huddinge, Sweden. Roger.Stromberg@ki.se.
  • Murtola M; Department of Biosciences and Nutrition, Karolinska Institutet, Neo, 141 83 Huddinge, Sweden. Roger.Stromberg@ki.se.
  • Strömberg R; Oligonucleotide Discovery, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Chem Commun (Camb) ; 57(83): 10911-10914, 2021 Oct 19.
Article in English | MEDLINE | ID: covidwho-1488037
ABSTRACT
We present Zn2+-dependent dimethyl-dipyridophenazine PNA conjugates as efficient RNA cleaving artificial enzymes. These PNAzymes display site-specific RNA cleavage with 10 minute half-lives and cleave clinically relevant RNA models.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Phenazines / Pyridines / RNA / Peptide Nucleic Acids Type of study: Prognostic study Language: English Journal: Chem Commun (Camb) Journal subject: Chemistry Year: 2021 Document Type: Article Affiliation country: D1cc04383h

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Phenazines / Pyridines / RNA / Peptide Nucleic Acids Type of study: Prognostic study Language: English Journal: Chem Commun (Camb) Journal subject: Chemistry Year: 2021 Document Type: Article Affiliation country: D1cc04383h