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Growth Differentiation Factor 15 (GDF-15): A Novel Biomarker Associated with Poorer Respiratory Function in COVID-19.
Alserawan, Leticia; Peñacoba, Patricia; Orozco Echevarría, Sandra Elizabet; Castillo, Diego; Ortiz, Esther; Martínez-Martínez, Laura; Moga Naranjo, Esther; Domingo, Pere; Castellví, Ivan; Juárez, Cándido; Mariscal, Anaís.
  • Alserawan L; Department of Immunology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), 08041 Barcelona, Spain.
  • Peñacoba P; Department of Respiratory Medicine, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain.
  • Orozco Echevarría SE; Department of Respiratory Medicine, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain.
  • Castillo D; Department of Respiratory Medicine, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain.
  • Ortiz E; Department of Immunology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), 08041 Barcelona, Spain.
  • Martínez-Martínez L; Department of Immunology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), 08041 Barcelona, Spain.
  • Moga Naranjo E; Department of Immunology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), 08041 Barcelona, Spain.
  • Domingo P; Department of Internal Medicine, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain.
  • Castellví I; Department of Rheumatology, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain.
  • Juárez C; Department of Immunology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), 08041 Barcelona, Spain.
  • Mariscal A; Department of Immunology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), 08041 Barcelona, Spain.
Diagnostics (Basel) ; 11(11)2021 Oct 27.
Article in English | MEDLINE | ID: covidwho-1488511
ABSTRACT
It is essential to find new biomarkers for severity stratification of patients with coronavirus disease (COVID-19). Growth differentiation factor 15 (GDF-15) is upregulated in pathological conditions that involve inflammation and/or oxidative stress. We determined circulating levels of GDF-15 and correlated them with clinical and laboratory parameters reflecting severity in 84 patients with COVID-19, finding that GDF-15 levels were higher in both patients than in 20 healthy controls and were higher in patients with poorer respiratory function. GDF-15 levels also correlated with interleukin-6, C-reactive protein, ferritin and D-dimer levels and with neutrophilia and lymphopenia. Of all the analysed biomarkers, GDF-15 showed the best area under the receiver operating characteristics curve in identifying patients with poor respiratory function. In conclusion, our data support GDF-15 as a biomarker associated with pulmonary impairment in COVID-19 and so can potentially be useful in stratifying COVID-19 cases by severity.
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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Type of study: Observational study / Prognostic study / Risk factors Language: English Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Type of study: Observational study / Prognostic study / Risk factors Language: English Year: 2021
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