Association between inflammation markers in patients with SARSCoV-2 with the development and severity of AKI

ABSTRACT

Background: Acute Kidney Injure (AKI) is a common complication associated with SARS-CoV2 infection. Sepsis, direct cellular injury due to the tropism of the virus, and systemic inflammation are mechanisms involved in its development. Methods: Prospective Cohort from March-2020 to March-2021 including 200 patients ≥18 yrs with SARS CoV2 for RT-PCR. All patients with development of AKI (KDIGO classification) during their hospitalization were registered. Age, gender, hospitalization time, oxygen use, SOFA, APACHE II, BRESCIA, PAFI, Leukocytes, creatinine (CrS) andinflammation markers (procalcitonin, ferritin, RCP, LDH, D-dimer) were registered. Results: The incidence of AKI was 40%, 77% were male, 64% had AKI 1 and 36% were AKIN 2 y 3. The use of higher supplemental oxygen, APACHE, BRESCIA, D-Dimer and procalcitonin at day 9 and 12 were associated with AKI. In a logistic regression analysis, risk factor to AKI was septic shock (RR;1.7-117;p=0.013). Other results are shown in Table Conclusions: Inflammatory markers (d-Dimer and procalcitonin) were associated with the development and severity of AKI but only septic shock was predictive of the development of AKI.