Immunizations with diverse sarbecovirus receptor binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability
Immunity
; 2021.
Article
in English
| EuropePMC | ID: covidwho-1489418
ABSTRACT
Viral mutations are an emerging concern in reducing SARS-CoV-2 vaccination efficacy. Burnett et al. immunized humanized mice with different diverse sarbecovirus RBDs to elicit antibodies targeting conserved sites. Non-neutralizing cross-reactive antibodies targeting the conserved class 4 epitope were readily elicited. Neutralizing ability was reserved only for antibodies binding this conserved supersite through an elongated CDRH3 that obstructed ACE2-RBD interactions.
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Collection:
Databases of international organizations
Database:
EuropePMC
Language:
English
Journal:
Immunity
Year:
2021
Document Type:
Article
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