Interim analysis of the cosa registry: COVID-19 patients treated with the seraph® 100 microbind® affinity filter
Journal of the American Society of Nephrology
; 32:79-80, 2021.
Article
in English
| EMBASE | ID: covidwho-1490102
ABSTRACT
Background:
The Seraph®100 Microbind Affinity Blood Filter® is a hemofiltration device that is licensed for pathogen reduction in the blood that received an emergency authorization for the treatment of COVID-19 by the FDA. The aim of this registry was to evaluate safety and efficacy of Seraph 100 treatment for COVID-19 patients.Methods:
This is an online registry in which main patient charcteristics, treatment characteristics and outcome parameters of COVID-19 patients, treated with the Seraph100 can be documented without reimbursement.Results:
Seventy-five treatment sessions in 60 patients from 12 hospitals were documented in the registry (Fig 1). Overall mortality was 42.3%. Adverse events of the Seraph® 100 treatment were reported in 8 (10.6 %) of the 75 treatments. Eight (10.6 %) of all the procedures ended prematurely due to circuit failure. Non-survivor had a higher rate of bacterial superinfection, higher level of inflammatory laboratory markers (procalcitonin and ferritin) and higher d-dimer levels(Fig 2). While predicted mortality according to SOFA score in ICU patients was >80 %, the observed mortality was 47.6 %. In non-ICU patients, 4C score predicted a mortality of 31.4-34.9 % while the observed mortality was 22.2 %.Conclusions:
Seraph 100 treatment was well tolerated and circuit failure rate was significantly lower than reported for KRT in COVID-19 patients. Compared to the calculated mortality, the observed mortality in the registry was lower.
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Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Journal of the American Society of Nephrology
Year:
2021
Document Type:
Article
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