Your browser doesn't support javascript.
Inflammation-related adverse reactions following vaccination potentially indicate a stronger immune response.
Zhuang, Chun-Lan; Lin, Zhi-Jie; Bi, Zhao-Feng; Qiu, Ling-Xian; Hu, Fang-Fang; Liu, Xiao-Hui; Lin, Bi-Zhen; Su, Ying-Ying; Pan, Hui-Rong; Zhang, Tian-Ying; Huang, Shou-Jie; Hu, Yue-Mei; Qiao, You-Lin; Zhu, Feng-Cai; Wu, Ting; Zhang, Jun; Xia, Ning-Shao.
  • Zhuang CL; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Strait Collaborative Innovation Center of Biomedicine and Pharmaceutics, School of Public Health, Xiamen University, Xiamen, People's Republic of
  • Lin ZJ; Xiamen Innovax Biotech CO., Ltd., Xiamen, People's Republic of China.
  • Bi ZF; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Strait Collaborative Innovation Center of Biomedicine and Pharmaceutics, School of Public Health, Xiamen University, Xiamen, People's Republic of
  • Qiu LX; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Strait Collaborative Innovation Center of Biomedicine and Pharmaceutics, School of Public Health, Xiamen University, Xiamen, People's Republic of
  • Hu FF; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Strait Collaborative Innovation Center of Biomedicine and Pharmaceutics, School of Public Health, Xiamen University, Xiamen, People's Republic of
  • Liu XH; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Strait Collaborative Innovation Center of Biomedicine and Pharmaceutics, School of Public Health, Xiamen University, Xiamen, People's Republic of
  • Lin BZ; Xiamen Innovax Biotech CO., Ltd., Xiamen, People's Republic of China.
  • Su YY; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Strait Collaborative Innovation Center of Biomedicine and Pharmaceutics, School of Public Health, Xiamen University, Xiamen, People's Republic of
  • Pan HR; Xiamen Innovax Biotech CO., Ltd., Xiamen, People's Republic of China.
  • Zhang TY; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Strait Collaborative Innovation Center of Biomedicine and Pharmaceutics, School of Public Health, Xiamen University, Xiamen, People's Republic of
  • Huang SJ; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Strait Collaborative Innovation Center of Biomedicine and Pharmaceutics, School of Public Health, Xiamen University, Xiamen, People's Republic of
  • Hu YM; Jiangsu Provincial Center for Disease Control and Prevention, Public Health research institute of Jiangsu Province, Nanjing, People's Republic of China.
  • Qiao YL; Chinese Academy of Medical Sciences/Peking Union Medical College School of Population Medicine and Public Health, Beijing, People's Republic of China.
  • Zhu FC; Jiangsu Provincial Center for Disease Control and Prevention, Public Health research institute of Jiangsu Province, Nanjing, People's Republic of China.
  • Wu T; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Strait Collaborative Innovation Center of Biomedicine and Pharmaceutics, School of Public Health, Xiamen University, Xiamen, People's Republic of
  • Zhang J; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Strait Collaborative Innovation Center of Biomedicine and Pharmaceutics, School of Public Health, Xiamen University, Xiamen, People's Republic of
  • Xia NS; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Strait Collaborative Innovation Center of Biomedicine and Pharmaceutics, School of Public Health, Xiamen University, Xiamen, People's Republic of
Emerg Microbes Infect ; 10(1): 365-375, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1490458
Semantic information from SemMedBD (by NLM)
1. Vaccination AFFECTS Immune response
Subject
Vaccination
Predicate
AFFECTS
Object
Immune response
2. Human papillomavirus 16 PROCESS_OF Participant
Subject
Human papillomavirus 16
Predicate
PROCESS_OF
Object
Participant
3. Human papillomavirus 18 PROCESS_OF Participant
Subject
Human papillomavirus 18
Predicate
PROCESS_OF
Object
Participant
4. Symptoms PROCESS_OF Participant
Subject
Symptoms
Predicate
PROCESS_OF
Object
Participant
5. Vaccines CAUSES Immunoglobulin level - finding
Subject
Vaccines
Predicate
CAUSES
Object
Immunoglobulin level - finding
6. Vaccination AFFECTS Immune response
Subject
Vaccination
Predicate
AFFECTS
Object
Immune response
7. Human papillomavirus 16 PROCESS_OF Participant
Subject
Human papillomavirus 16
Predicate
PROCESS_OF
Object
Participant
8. Human papillomavirus 18 PROCESS_OF Participant
Subject
Human papillomavirus 18
Predicate
PROCESS_OF
Object
Participant
9. Symptoms PROCESS_OF Participant
Subject
Symptoms
Predicate
PROCESS_OF
Object
Participant
10. Vaccines CAUSES Immunoglobulin level - finding
Subject
Vaccines
Predicate
CAUSES
Object
Immunoglobulin level - finding
ABSTRACT
Concerns about vaccine safety are an important reason for vaccine hesitancy, however, limited information is available on whether common adverse reactions following vaccination affect the immune response. Data from three clinical trials of recombinant vaccines were used in this post hoc analysis to assess the correlation between inflammation-related solicited adverse reactions (ISARs, including local pain, redness, swelling or induration and systematic fever) and immune responses after vaccination. In the phase III trial of the bivalent HPV-16/18 vaccine (Cecolin®), the geometric mean concentrations (GMCs) for IgG anti-HPV-16 and -18 (P<0.001) were significantly higher in participants with any ISAR following vaccination than in those without an ISAR. Local pain, induration, swelling and systemic fever were significantly correlated with higher GMCs for IgG anti-HPV-16 and/or anti-HPV-18, respectively. Furthermore, the analyses of the immunogenicity bridging study of Cecolin® and the phase III trial of a hepatitis E vaccine yielded similar results. Based on these results, we built a scoring model to quantify the inflammation reactions and found that the high score of ISAR indicates the strong vaccine-induced antibody level. In conclusion, this study suggests inflammation-related adverse reactions following vaccination potentially indicate a stronger immune response.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Hepatitis Vaccines / Vaccines, Synthetic / Hepatitis E / Papillomavirus Infections / Human papillomavirus 16 / Human papillomavirus 18 / Papillomavirus Vaccines Type of study: Controlled clinical trial / Prognostic study / Randomized controlled trials Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Emerg Microbes Infect Year: 2021 Document Type: Article

Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Hepatitis Vaccines / Vaccines, Synthetic / Hepatitis E / Papillomavirus Infections / Human papillomavirus 16 / Human papillomavirus 18 / Papillomavirus Vaccines Type of study: Controlled clinical trial / Prognostic study / Randomized controlled trials Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Emerg Microbes Infect Year: 2021 Document Type: Article