The effect of glutamine supplementation on serum levels of some inflammatory factors, oxidative stress, and appetite in COVID-19 patients: a case-control study.
Inflammopharmacology
; 29(6): 1769-1776, 2021 Dec.
Article
in English
| MEDLINE | ID: covidwho-1491279
ABSTRACT
BACKGROUND:
Malnutrition is seen in COVID-19 patients, and reducing malnutrition with appropriate therapies may improve these patients' health. This case-control study aimed to assess and compare serum levels of some inflammatory factors, oxidative stress, and appetite in COVID-19 patients with respiratory infections that receive glutamine treatment with a control group.METHODS:
In this study, patients who consented to use glutamine were considered as the case group and other patients who did not use glutamine were considered as a control group. Two hundred twenty-two COVID-19 patients (51.2 ± 6.7) using L-Glutamine and 230 COVID-19 patients (51.3 ± 8.2) with similar age, gender, and clinical status, as the control group, were included in the study. For 5 days, the case group consumed 10 g of glutamine supplement three times per day. At the end of the 5 days, blood samples were taken again to test for serum levels of IL1ß, tumor necrosis factor-α, malondialdehyde, and total antioxidant capacity, then all data were analyzed.RESULTS:
Serum levels of ß-1 interleukin, tumor necrosis factor-α and hs-CRP were significantly reduced with five days of glutamine supplementation (p < 0.05), and patients' appetite during 5 days of glutamine supplementation compared with the control group had a significant increase (p < 0.05).CONCLUSION:
Glutamine supplementation in COVID-19 patients with respiratory infection significantly reduces serum levels of interleukin-1 ß, hs-CRP, and tumor necrosis factor-α and significantly increases appetite, so glutamine supplementation may be useful for COVID-19 patients in the hospital.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Appetite
/
Tumor Necrosis Factor-alpha
/
Oxidative Stress
/
Interleukin-1beta
/
COVID-19 Drug Treatment
/
Glutamine
/
Inflammation
/
Malondialdehyde
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
Topics:
Traditional medicine
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Inflammopharmacology
Journal subject:
Pharmacology
/
Drug Therapy
Year:
2021
Document Type:
Article
Affiliation country:
S10787-021-00881-0
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