Preadmission usage of metformin and mortality in COVID-19 patients including the post-discharge period.
Ir J Med Sci
; 191(2): 569-575, 2022 Apr.
Article
in English
| MEDLINE | ID: covidwho-1491362
ABSTRACT
BACKGROUND:
The effect of preadmission metformin usage (PMU) on the mortality of coronavirus disease-2019 (COVID-19) patients with diabetes is conflicting. Most studies have focused on in-hospital mortality; however, mortality after discharge also increases in COVID-19 patients.AIMS:
Examining the effect of PMU on all-cause mortality, including the post-discharge period.METHODS:
Patients with diabetes who were hospitalised in 2020 due to COVID-19 were included in the study. They were divided into two groups those with a history of metformin use (MF( +)) and those without such history (MF( -)). Propensity score matching (PSM) was performed at a ratio of 11 for age and sex. COX regression analyses were used to demonstrate risk factors for mortality.RESULTS:
We investigated 4103 patients hospitalised for COVID-19. After excluding those without diabetes or with chronic liver/kidney disease, we included the remaining 586 patients, constituting 293 women (50%) with an overall mean age of 66 ± 11.9 years. After PSM analysis, the in-hospital and post-discharge mortality rates were higher in the MF( -) group though not significantly different. However, overall mortality was higher in the MF( -) group (51 (42.5%) vs. 35 (29.2%), p = 0.031). For overall mortality, the adjusted HR was 0.585 (95% CI 0.371 - 0.920, p = 0.020) in the MF( +) group.CONCLUSION:
PMU is associated with reducing all-cause mortality. This effect starts from the in-hospital period and becomes more significant with the post-discharge period. The main limitations were the inability to evaluate the compliance with metformin and the effects of other medications due to retrospective nature.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Diabetes Mellitus, Type 2
/
COVID-19 Drug Treatment
/
Metformin
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Topics:
Long Covid
Limits:
Aged
/
Female
/
Humans
/
Middle aged
Language:
English
Journal:
Ir J Med Sci
Year:
2022
Document Type:
Article
Affiliation country:
S11845-021-02823-9
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